MP83-10 CLINICAL EFFICACY OF SUB-STAGING AND EN-BLOC TUR SPECIMEN FOR PT1 BLADDER CANCER

Abstract

You have accessJournal of UrologyBladder Cancer: Non-invasive II1 Apr 2018MP83-10 CLINICAL EFFICACY OF SUB-STAGING AND EN-BLOC TUR SPECIMEN FOR PT1 BLADDER CANCER Takafumi Yanagisawa, Jun Miki, Takashi Yorozu, Akihiro Matsukawa, Yuzo Inaba, Kosuke Iwatani, Kagenori Ito, Hajime Onuma, Keiji Yasue, Seiro Tanaka, Takahiro Kimura, Hiroyuki Takahashi, Koichi Kishimoto, and Shin Egawa Takafumi YanagisawaTakafumi Yanagisawa More articles by this author , Jun MikiJun Miki More articles by this author , Takashi YorozuTakashi Yorozu More articles by this author , Akihiro MatsukawaAkihiro Matsukawa More articles by this author , Yuzo InabaYuzo Inaba More articles by this author , Kosuke IwataniKosuke Iwatani More articles by this author , Kagenori ItoKagenori Ito More articles by this author , Hajime OnumaHajime Onuma More articles by this author , Keiji YasueKeiji Yasue More articles by this author , Seiro TanakaSeiro Tanaka More articles by this author , Takahiro KimuraTakahiro Kimura More articles by this author , Hiroyuki TakahashiHiroyuki Takahashi More articles by this author , Koichi KishimotoKoichi Kishimoto More articles by this author , and Shin EgawaShin Egawa More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2758AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES T1 bladder cancer has various pathological features individually, and has high rate of not only recurrence but progression. Some studies have reported sub-staging of T1 bladder cancer could be prognostic factor of progression, but it hadn't become widespread yet. We evaluated correlation between sub-staging and oncological outcome, and compared conventional TUR-BT with En-bloc TUR-BT. METHODS We retrospectively analyzed the record of the 90 patients who were diagnosed as pT1 bladder cancer in our institution between November 2011 and June 2017. We compared conventional TUR-BT(n=72) with En-bloc TUR-BT(n=18) about pathological and oncological outcome. All specimens were reviewed by single urological pathologist and diagnosed pT1a/b staged vertically by muscularis mucosae(MM). RESULTS Median follow up period was 21 months. The overall 3-year recurrence-free survival rate was 69.6%, and the 3-year progression-free survival rate was 85.1%. There was significant difference in progression by pT1a/b sub-staging, the 3-year progression-free survival was pT1a (n=30): 100% and pT1b (n=36): 68.1% (p=0.01). In comparison with conventional TUR-BT and En-bloc TUR-BT, there was no significant difference in patient characteristics, tumor size and outfit. Median follow up period of TUR-BT was 22 months and of En-bloc TUR was 10 months, the 2-year recurrence-free survival rate was 76.1% vs. 76.4%, and the 2-year progression-free survival rate was 86.1% vs. 100%, respectively (p=0.2). The diagnose rate of T1a/b sub-staging in TUR-BT was only 77.6%, but that of En-bloc TUR-BT was 100% (p=0.01). CONCLUSIONS Vertical invasion such as pT1a/b sub-staging of T1 bladder cancer could be prognostic factor of progression. En-bloc TUR specimen can lead to more accurate sub-staging diagnosis compared with conventional TUR-BT specimen. Further investigation with long-term follow-up is needed. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e1119-e1120 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Takafumi Yanagisawa More articles by this author Jun Miki More articles by this author Takashi Yorozu More articles by this author Akihiro Matsukawa More articles by this author Yuzo Inaba More articles by this author Kosuke Iwatani More articles by this author Kagenori Ito More articles by this author Hajime Onuma More articles by this author Keiji Yasue More articles by this author Seiro Tanaka More articles by this author Takahiro Kimura More articles by this author Hiroyuki Takahashi More articles by this author Koichi Kishimoto More articles by this author Shin Egawa More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...