MP81-20 SNP RS7824364 INCREASES THE RISK OF A POSITIVE PROSTATE CANCER BIOPSY: RESULTS FROM THE PREDICTION OF PROSTATE CANCER AMONG AFRICAN AMERICAN AND PUERTO RICAN MEN (POPCAP) STUDY

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You have accessJournal of UrologyProstate Cancer: Detection & Screening VIII (MP81)1 Apr 2020MP81-20 SNP RS7824364 INCREASES THE RISK OF A POSITIVE PROSTATE CANCER BIOPSY: RESULTS FROM THE PREDICTION OF PROSTATE CANCER AMONG AFRICAN AMERICAN AND PUERTO RICAN MEN (POPCAP) STUDY Lisly Chery*, Graciela M. Nogueras Gonzalez, Jian Gu, Chad Huff, Arun Sreekumar, Jeff Jones, Don Griffith, Steven Canfield, Xuemei Wang, Xuelin Huang, Pamela Roberson, Patricia Troncoso, Michael Ittmann, Michael Scheurer, Margarita Irizarry-Ramirez, and Curtis Pettaway Lisly Chery*Lisly Chery* More articles by this author , Graciela M. Nogueras GonzalezGraciela M. Nogueras Gonzalez More articles by this author , Jian GuJian Gu More articles by this author , Chad HuffChad Huff More articles by this author , Arun SreekumarArun Sreekumar More articles by this author , Jeff JonesJeff Jones More articles by this author , Don GriffithDon Griffith More articles by this author , Steven CanfieldSteven Canfield More articles by this author , Xuemei WangXuemei Wang More articles by this author , Xuelin HuangXuelin Huang More articles by this author , Pamela RobersonPamela Roberson More articles by this author , Patricia TroncosoPatricia Troncoso More articles by this author , Michael IttmannMichael Ittmann More articles by this author , Michael ScheurerMichael Scheurer More articles by this author , Margarita Irizarry-RamirezMargarita Irizarry-Ramirez More articles by this author , and Curtis PettawayCurtis Pettaway More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000973.020AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We previously found that the 8q24 single nucleotide polymorphism (SNP) rs7824364 was associated with prostate cancer (PCa) among African American (AA) and Puerto Rican PCa cases versus controls. In this study, we have analyzed this same PCa related SNP in a prospectively collected cohort of AA men prior to prostate biopsy to determine correlations with a subsequent PCa diagnosis. METHODS: One hundred ninety-nine AA men underwent prostate biopsy for either serum PSA ≥2.5ng/ml or abnormal digital rectal exam (DRE) as a part of the study at three different academic institutions. Blood was drawn from participants prior to biopsy to extract DNA for genotyping SNP rs7824363 using Taqman method. We assessed total PSA, free PSA, and -2 pro PSA (p2PSA). PHI was calculated as [(p2PSA/freePSA) x (PSA)(½)]. Wilcoxon rank sum was used to compare genotype distribution and serum biomarker distributions between groups (i.e. with/without cancer) and multivariate logistic regression models used to determine the association of SNP with disease status. RESULTS: One hundred twenty-five men [61.3%] were diagnosed with prostate cancer subsequent to biopsy. PCa grade groups were 1, 2, 3, and ≥ 4 in 24 (19.2%), 38 (30.4%), 20 (16.0%), and 43 (34.4%) of the patients with cancer. Rs7824364 genotypes were wild-type in 102 (TT=57%) and variant in 78 (CT/CC =43%) subjects. Cancer incidence increased from 53/101 (52%) to 55/74 (74%) comparing TT with CT/CC genotypes. Median PSA (5.3 vs.7.2), P2PSA (13.0 vs 16.5), PHI (26.5 vs. 53.0), %fPSA (18.6 vs. 10.7), previous prostate biopsy (8.3 vs 28%) and abnormal DRE (43 vs 26%) were all significantly different in AA men with cancer than those without. Multivariate predictors of a positive biopsy included PHI, abnormal DRE, and prior negative biopsy (p=0.014-0.008). Individuals carrying the rs7824364 variant genotypes (CT/CC) exhibited an increased risk of being biopsy positive (odds ratio = 2.17, 95% confidence interval 0.84 - 5.60, p=0.11). CONCLUSIONS: The variant (CT/CC) genotypes of SNP rs7824364 increased the risk of a positive prostate biopsy among AA men. Incorporation with other PCa related SNPs could further improve prognostication. Source of Funding: National Cancer Institute- U54 CS 96300/U54 CA 96297 © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1244-e1244 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Lisly Chery* More articles by this author Graciela M. Nogueras Gonzalez More articles by this author Jian Gu More articles by this author Chad Huff More articles by this author Arun Sreekumar More articles by this author Jeff Jones More articles by this author Don Griffith More articles by this author Steven Canfield More articles by this author Xuemei Wang More articles by this author Xuelin Huang More articles by this author Pamela Roberson More articles by this author Patricia Troncoso More articles by this author Michael Ittmann More articles by this author Michael Scheurer More articles by this author Margarita Irizarry-Ramirez More articles by this author Curtis Pettaway More articles by this author Expand All Advertisement PDF downloadLoading ...