MP81-19 ANDROGEN RECEPTOR CAG REPEAT LENGTH AS A RISK FACTOR OF LATE ONSET HYPOGONADISM IN A KOREAN MALE POPULATION

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Basic Research & Pathophysiology II1 Apr 2017MP81-19 ANDROGEN RECEPTOR CAG REPEAT LENGTH AS A RISK FACTOR OF LATE ONSET HYPOGONADISM IN A KOREAN MALE POPULATION Sun Tae Ahn, Hyeong Guk Jeong, Ji Yun Chae, Jong Wook Kim, Mi Mi Oh, Hong Seok Park, Je jong Kim, and Du Geon Moon Sun Tae AhnSun Tae Ahn More articles by this author , Hyeong Guk JeongHyeong Guk Jeong More articles by this author , Ji Yun ChaeJi Yun Chae More articles by this author , Jong Wook KimJong Wook Kim More articles by this author , Mi Mi OhMi Mi Oh More articles by this author , Hong Seok ParkHong Seok Park More articles by this author , Je jong KimJe jong Kim More articles by this author , and Du Geon MoonDu Geon Moon More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2545AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Androgen receptor (AR) CAG polymorphism that modulates the effect of testosterone has been found to influence sexual function. However, correlation between AR CAG repeat length and clinical factors of late onset hypogonadism is unclear and there are only few studies from Asian population. In this study we explored the relationship between AR CAG repeat length polymorphism and late onset hypogonadism (LOH) in a Korean male population. METHODS The association between AR CAG repeat length was analyzed in a total 263 Korean men from 2014 to 2015. LOH was diagnosed by serum testosterone level of <3.5ng/mL and androgen deficiency in the aging male questionnaire positive. AR CAG repeat length was determined by microsatellite fragment sizing. Clinical factors and questionnaire related with LOH (patient health questionnaire-9 (PHQ), aging male symptom scale (AMS), and international index of erectile function (IIEF-5)) were analyzed with AR CAG repeat length. RESULTS Mean age of the patients was 61.2±10.9 years and mean AR CAG repeat length was 26.2±5.1. Mean serum testosterone levels was 2.6±0.4 in men with LOH and 6.0±2.0 in men without LOH, respectively. A Total of 33 men (12.5%) were diagnosed with LOH. Men with LOH showed significant longer AR CAG repeat length compared with men without LOH (30.1 vs 25.6, p<0.001). As CAG repeat length increased, AMS total and AMS psychotic/somatic/sexual subscore increased(r=0.219 r=0.168, r=0.160, r=0.241) (p=0.001,p=0.006 p=0.001, p=0.001) and IIEF-5 score decreased, significantly (r=-0.187 p=0.002). In multivariate analysis showed that CAG was independently associated with LOH. (OR=1.3, P<0.001) CONCLUSIONS AR CAG repeat length was associated with prevalence of LOH and clinical symptoms of LOH in a Korean male population. Longer CAG repeat length was identified as a risk factor of LOH in Korean male. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1096 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Sun Tae Ahn More articles by this author Hyeong Guk Jeong More articles by this author Ji Yun Chae More articles by this author Jong Wook Kim More articles by this author Mi Mi Oh More articles by this author Hong Seok Park More articles by this author Je jong Kim More articles by this author Du Geon Moon More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...