MP81-13 ROLE OF 18F-FDG PET/CT IN IDENTIFYING INGUINAL NODAL METASTASIS IN PATIENTS ON SURVEILLANCE AFTER PRIMARY TREATMENT OF PENILE SQUAMOUS CELL CARCINOMA- SINGLE CENTRE PROSPECTIVE STUDY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Penis/Testis/Urethra: Benign Disease & Malignant Disease II1 Apr 2016MP81-13 ROLE OF 18F-FDG PET/CT IN IDENTIFYING INGUINAL NODAL METASTASIS IN PATIENTS ON SURVEILLANCE AFTER PRIMARY TREATMENT OF PENILE SQUAMOUS CELL CARCINOMA- SINGLE CENTRE PROSPECTIVE STUDY Yuvaraja Thyavihally, Santosh Waigaonkar, Abhinav Pednekar, Nikhil Dharmadhikari, Harshvardhan Rao, Nikhil Gulavani, Tirathram Kaushik, Mrunal Parab, Kalyan Chakradhar, and Amit Patil Yuvaraja ThyavihallyYuvaraja Thyavihally More articles by this author , Santosh WaigaonkarSantosh Waigaonkar More articles by this author , Abhinav PednekarAbhinav Pednekar More articles by this author , Nikhil DharmadhikariNikhil Dharmadhikari More articles by this author , Harshvardhan RaoHarshvardhan Rao More articles by this author , Nikhil GulavaniNikhil Gulavani More articles by this author , Tirathram KaushikTirathram Kaushik More articles by this author , Mrunal ParabMrunal Parab More articles by this author , Kalyan ChakradharKalyan Chakradhar More articles by this author , and Amit PatilAmit Patil More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2066AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The extent of lymph node involvement is the most relevant prognostic factor in patients with penile cancer. Management of clinically normal groin nodes (N0 groin) in patients with carcinoma of penis is controversial. Aim of our prospective study was to assess the role of 2-18 fluro-2-deoxy-D-glucose positron emission tomography– computerized tomography (PET-CT) in detecting lymph node metastasis in carcinoma penis with clinically N0 groin during follow up. METHODS Nineteen patients (38 groins) who had clinically N0 groin and PET scan negative chose close observation of groin after primary treatment of penile cancer. 14 patients were low risk and 5 were high risk for metastasis based on primary tumor histopathology. Follow up protocol included clinical examination, ultrasonographhy of groin every three months and PET scan at 3, 6, 12, 18,24,36,48 months in high risk group and 6, 12, 24,36,48 months in low risk group. Data was collected prospectively and analysed. Follow up period ranged from 12 -48 months (median 22). RESULTS Six out of 19 patients had PET uptake during follow up. 3 /5 patients of high risk were PET positive. One was positive at 6 months (bilateral, palpable), second was positive at 12 months and 18 months (rt –palpable and left), other at 24 months (unilateral) and in total 5/10 groins of high risk were positive for PET. 3/14 patients with low risk were PET positive. One developed PET uptake at 12 months (Unilateral), other at 12 and 24 months (bilateral), third one at 28 months (unilateral- had palpable disease) and in total 4/28 groins of low risk were positive for PET. All 9 groins which had PET uptake underwent groin node dissection (GND) out of which one was negative for metastasis. One patient had clinical node enlargement but PET was negative. Our test showed sensitivity of 88%, specificity of 96%, positive predictive value of 88% and negative predictive value of 96% in detecting groin node metastasis during follow up. CONCLUSIONS 18F-FDG-PET/CT is a promising staging tool in assessing the inguinal lymph node involvement of patients with penile carcinoma. Our results show that PET CT is useful in following up groin of patients with ca penis after primary treatment. It is a promising investigation which can identify early metastases. Limitation of this study was less number of patients, not confirming negative groins by histopathology and was based on clinical examination. However further follow up of these patients is required to identify late recurrences. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1058 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Yuvaraja Thyavihally More articles by this author Santosh Waigaonkar More articles by this author Abhinav Pednekar More articles by this author Nikhil Dharmadhikari More articles by this author Harshvardhan Rao More articles by this author Nikhil Gulavani More articles by this author Tirathram Kaushik More articles by this author Mrunal Parab More articles by this author Kalyan Chakradhar More articles by this author Amit Patil More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...