MP80-16 RISING INCIDENCE OF HYPEROXALURIA IN STONE-FORMING PATIENTS: CHRONOLOGICAL AND GEOGRAPHICAL DIFFERENCES

Abstract

You have accessJournal of UrologyStone Disease: Evaluation II1 Apr 2015MP80-16 RISING INCIDENCE OF HYPEROXALURIA IN STONE-FORMING PATIENTS: CHRONOLOGICAL AND GEOGRAPHICAL DIFFERENCES Kyle Spradling, Zhamshid Okhunov, Melissa Suarez, Jaime Landman, and Ramy Youssef Kyle SpradlingKyle Spradling More articles by this author , Zhamshid OkhunovZhamshid Okhunov More articles by this author , Melissa SuarezMelissa Suarez More articles by this author , Jaime LandmanJaime Landman More articles by this author , and Ramy YoussefRamy Youssef More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2852AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The global incidence of kidney stones is rising and calcium oxalate is the most common type of stone worldwide. Hyperoxaluria is a well-known risk factor for calcium oxalate urolithiasis; however, long-term epidemiological trends in hyperoxaluria have been largely unexplored. Herein we report chronological and geographical trends related to hyperoxaluria in stone-forming patients. METHODS We systematically reviewed the existing literature between 1991 and 2014, seeking studies that assessed for hyperoxaluria (>45mg/day) in recurrent stone formers. Studies that performed 24-hour urine analysis for urine oxalate levels in patients with a history of recurrent calcium stones were included. The literature search provided 16 peer-reviewed manuscripts that were eligible for inclusion, involving 3,074 patients in total. Studies were divided chronologically (1991 – 2000 vs. 2001 – 2014) and geographically (U.S. studies vs. non-U.S. studies) and hyperoxaluria incidences were compared between groups. RESULTS Five studies involving 1,150 patients were performed between 1991 – 2000, and 11 studies involving 1,924 patients were performed between 2001 – 2014. Eight studies representing patient populations in 7 non-U.S. countries were included in the analysis. The incidence of hyperoxaluria in stone-forming patient cohorts was 24.8% and 39.4% (p < 0.001) in studies performed between 1991 – 2000 and 2001 – 2014, respectively. Among the studies performed after 2000, incidence of hyperoxaluria was significantly higher in non-U.S. cohorts compared to U.S. patient cohorts (45.0% vs. 28.8%, p < 0.001). CONCLUSIONS The incidence of hyperoxaluria in stone-forming patients has increased over the last two decades and may be a significant contributing factor to the rising global incidence of urolithiasis. A geographical disparity in hyperoxaluria may exist between U.S. and non-U.S. stone-formers. Future studies are needed to explain these epidemiological trends in hyperoxaluria and their consequences. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e1025 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kyle Spradling More articles by this author Zhamshid Okhunov More articles by this author Melissa Suarez More articles by this author Jaime Landman More articles by this author Ramy Youssef More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...