MP80-12 A SIMPLIFIED EQUATION TO ESTIMATE NEW BASELINE RENAL FUNCTION AFTER RADICAL OR PARTIAL NEPHRECTOMY: DEVELOPMENT AND VALIDATION

Abstract

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging/Surveillance III (MP80)1 Apr 2020MP80-12 A SIMPLIFIED EQUATION TO ESTIMATE NEW BASELINE RENAL FUNCTION AFTER RADICAL OR PARTIAL NEPHRECTOMY: DEVELOPMENT AND VALIDATION Diego Aguilar Palacios*, Brigid Wilson, Mustafa Ascha, Sunah Song, Molly E. DeWitt-Foy, Steven C. Campbell, and Robert Abouassaly Diego Aguilar Palacios*Diego Aguilar Palacios* More articles by this author , Brigid WilsonBrigid Wilson More articles by this author , Mustafa AschaMustafa Ascha More articles by this author , Sunah SongSunah Song More articles by this author , Molly E. DeWitt-FoyMolly E. DeWitt-Foy More articles by this author , Steven C. CampbellSteven C. Campbell More articles by this author , and Robert AbouassalyRobert Abouassaly More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000972.012AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Preoperative estimation of new baseline glomerular filtration rate (GFR) after renal surgery for RCC has important clinical implications. Here we develop and externally validate an equation to estimate postoperative new baseline GFR. METHODS: A cohort of 8080 kidney cancer patients undergoing partial or radical nephrectomy (2005 -2015) in the veteran’s affair national health system was identified. All patients had both preoperative and new baseline GFR estimations by CKD-EPI. New baseline GFR was defined as the last GFR value 1-12 months after surgery. Patients with preoperative end-stage renal disease were excluded. Multivariable linear regression was used to create an equation to predict new baseline GFR using two-thirds of the cohort. The simplest equation with highest R2 was selected and tested. The equation was then internally validated in the remaining third of the cohort. For external validation, a cohort of 1121 patients from an outside tertiary care center was used. Correlation (R2), bias (median of observed GFR – predicted GFR), accuracy (percentage of predicted GFR values within 30% of observed GFR) and precision (interquartile range of observed GFR – predicted GFR) of equation were examined. RESULTS: Per multivariable analysis new baseline GFR = 18.10 + preoperative GFR (x0.70) – 17.89 (if radical nephrectomy) – 1.40 (if hypertension) – 2.20 (if diabetes). R2/ bias/ accuracy/ precision of equation were 0.64/-1.06/80/-8.7–7.4 and 0.64/0.87/79/-8.1–9.1 in the internal and external validation cohorts, respectively. CONCLUSIONS: Our analysis provides a simplified equation to predict postoperative new baseline renal function after renal surgery in kidney cancer patients that is highly accurate and externally validated. Source of Funding: Merit Pilot Award #PPO 17-216, VA Grant © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1229-e1230 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Diego Aguilar Palacios* More articles by this author Brigid Wilson More articles by this author Mustafa Ascha More articles by this author Sunah Song More articles by this author Molly E. DeWitt-Foy More articles by this author Steven C. Campbell More articles by this author Robert Abouassaly More articles by this author Expand All Advertisement PDF downloadLoading ...