Abstract
INTRODUCTION AND OBJECTIVES: Resveratrol(3,5,40-trihydroxy-trans-stilbene), a natural phytoalexin present in grapes, peanuts, mulberries and red wine, is thought to boost endothelial function by increasing endothelial nitric oxide synthase (eNOS) expression, by enhancing eNOS activity and by reduction of reacitive oxygen species (ROS) levels. Its effects on the function of the chronic ischemic bladder are not known. The objective of this study is to investigate the possible beneficial activities of resveratrol in a rat model of chronic ischemiarelated bladder dysfunction. METHODS: Male Sprague-Dawley rats were divided into control (n1⁄410), arterial endothelial injury (AI; n1⁄410), and AI with resveratrol treatment (AI-res; n1⁄410). AI and AI-res groups underwent endothelial injury of the iliac arteries and received a 2% cholesterol diet following AI. AI-res rats received resveratrol (1mg/kg/day) orally for 12 weeks. The control group received a regular diet. After 12 weeks, urodynamic investigation was performed in awake animals. RESULTS: Iliac arteries from both AI and AI-resveratrol rats showed neo-intimal formation and luminal occlusion. The body weight of the three groups had no difference. Micturition interval (MI), bladder capacity (Bcap) and voided volume (VV) in theAI groupwere significantly less than those in the control group (p<0.05). In the AI-res group MI, Bcap and VV were significantly larger than in the AI group (p<0.05), however, significantly less than in the control group (p<0.05)). (Fig.1) Contractile responses of bladder strips to electrical field stimulation (EFS) and carbachol (CCH)were lower inAI than incontrols; responses inpreparations from resveratrol-treated animals were similar to those of controls. (Fig.2) CONCLUSIONS: In the chronically ischemic rat bladder, treatment with resveratrol seems to have beneficial effect on bladder function, resulting in reduced bladder hyperactivity and reversed the low contractile responses to CCH and EFS. Source of Funding: none
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