MP79-09 ANTI-ANDROGEN THERAPY OVERCOMES THE TIME-DELAY IN INITIATION OF SALVAGE RADIATION THERAPY AND RESCUES ONCOLOGICAL OUTCOMES IN MEN WITH RECURRENT PROSTATE CANCER AFTER RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyProstate Cancer: Advanced (including Drug Therapy) IV (MP79)1 Apr 2020MP79-09 ANTI-ANDROGEN THERAPY OVERCOMES THE TIME-DELAY IN INITIATION OF SALVAGE RADIATION THERAPY AND RESCUES ONCOLOGICAL OUTCOMES IN MEN WITH RECURRENT PROSTATE CANCER AFTER RADICAL PROSTATECTOMY Akshay Sood*, Jacob Keeley, Deepansh Dalela, Sohrab Arora, Isaac Palma-Zamora, Marcus Jamil, Natalija Kovacevic, Guillaume Farah, Philip Olson, Wooju Jeong, Quoc-Dien Trinh, Craig G. Rogers, James O. Peabody, Mani Menon, and Firas Abdollah Akshay Sood*Akshay Sood* More articles by this author , Jacob KeeleyJacob Keeley More articles by this author , Deepansh DalelaDeepansh Dalela More articles by this author , Sohrab AroraSohrab Arora More articles by this author , Isaac Palma-ZamoraIsaac Palma-Zamora More articles by this author , Marcus JamilMarcus Jamil More articles by this author , Natalija KovacevicNatalija Kovacevic More articles by this author , Guillaume FarahGuillaume Farah More articles by this author , Philip OlsonPhilip Olson More articles by this author , Wooju JeongWooju Jeong More articles by this author , Quoc-Dien TrinhQuoc-Dien Trinh More articles by this author , Craig G. RogersCraig G. Rogers More articles by this author , James O. PeabodyJames O. Peabody More articles by this author , Mani MenonMani Menon More articles by this author , and Firas AbdollahFiras Abdollah More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000971.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To examine whether the addition of anti-androgen therapy (AAT) to ‘late’ salvage radiation therapy (sRT) can lead to oncological outcomes similar to that of early sRT in men with recurrent prostate cancer after radical prostatectomy. METHODS: Data on 670 men who participated in the RTOG 9601 trial and experienced biochemical recurrence were extracted using the NCTN data archive platform. Patients were stratified into four treatment groups: early sRT (pre-sRT PSA <0.7 ng/mL) with/without concomitant AAT and late sRT (pre-sRT PSA ³0.7 ng/mL) with/without concomitant AAT, based on the cut-offs reported in the original trial. Cox proportional hazards and Fine-Gray competing-risk regression analyses assessed the adjusted hazards of overall mortality, CaP specific mortality and metastatic/local disease progression among the four treatment groups. RESULTS: Patients were well-matched in baseline characteristics. The median follow-up was 12 years. At 10-years, for patients treated with early sRT, early sRT with AAT, late sRT and late sRT with AAT, the overall mortality, CaP specific mortality and metastasis rates were 14%, 16%, 31% and 17% (Log-rank p=0.0001), 7%, 3%, 16% and 4% (Gray’s p=0.0001) and 12%, 9%, 26% and 12% (Gray’s p=0.0003), respectively (Figure). Adjusted analysis demonstrated increased hazards of overall mortality in patients receiving delayed sRT versus early sRT, HR 1.62 (95% CI: 1.11 - 2.37). However, no difference remained after addition of concomitant AAT to late sRT ¾ referent early sRT, HR 0.89 (95% CI: 0.58 - 1.39). Similarly, the hazards of cancer-specific mortality and metastatic progression were worse for late sRT, when compared to early sRT, but were no different after addition of AAT to late sRT. CONCLUSIONS: Poorer outcomes associated with late sRT may be rescued with delivery of concomitant AAT. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1218-e1219 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Akshay Sood* More articles by this author Jacob Keeley More articles by this author Deepansh Dalela More articles by this author Sohrab Arora More articles by this author Isaac Palma-Zamora More articles by this author Marcus Jamil More articles by this author Natalija Kovacevic More articles by this author Guillaume Farah More articles by this author Philip Olson More articles by this author Wooju Jeong More articles by this author Quoc-Dien Trinh More articles by this author Craig G. Rogers More articles by this author James O. Peabody More articles by this author Mani Menon More articles by this author Firas Abdollah More articles by this author Expand All Advertisement PDF downloadLoading ...