MP78-08 RACIAL/ETHNIC PATTERNS IN THE PERFORMANCE OF MULTIPLEX URINE ERG AND PCA3 FOR PROSTATE CANCER DETECTION

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History III1 Apr 2014MP78-08 RACIAL/ETHNIC PATTERNS IN THE PERFORMANCE OF MULTIPLEX URINE ERG AND PCA3 FOR PROSTATE CANCER DETECTION Yongmei Chen, Jennifer Cullen, Aminia Ali, David G. McLeod, and Shiv Srivastava Yongmei ChenYongmei Chen More articles by this author , Jennifer CullenJennifer Cullen More articles by this author , Aminia AliAminia Ali More articles by this author , David G. McLeodDavid G. McLeod More articles by this author , and Shiv SrivastavaShiv Srivastava More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2491AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Introduction: Considering the limitations of PSA in prostate cancer (CaP) detection, a number of noninvasive and high specific tests have been developed for improving the prediction accuracy (PA) of CaP diagnosis. However, the racial/ethnic interactions with these biomarkers remain poorly understood. This study reports on the racial/ethnic patterns in the performance of urine ERG and PCA3 for CaP detection. METHODS Material and Methods: Data were collected from 306 men who underwent TRUS 12 core prostate biopsy. PCA3-, ERG-, and PSA-mRNA concentrations were quantified using the DTS® 400 system assay derived from first-catch urine samples following a DRE. The association of ERG score with clinical parameters were evaluated in whole biopsy cohort, as well as stratified by race/ethnicity; Secondly, PA estimates of biopsy result were quantified using area under the curve (AUC) of the receiver operator characteristic (ROC) analysis in multivariate logistic regression models, and assessed using cross-validation, in further, repeat these analyses in racial groups separately; Finally, quartile cutoffs were adopted to assess cancer risk in white and black men with extremes of ERG and PCA3 scores, respectively. RESULTS Of the 306 men in the study, 174 (57%) were diagnosed with CaP; 116 (38%) self-reported as black race/ethnicity. Median ERG score was significantly higher in white men (59 vs. 30, p = 0.03). Men diagnosed with CaP had much higher ERG score (67 vs. 24, p < .001) than men with a negative biopsy. This difference was widened among white biopsy group (85 vs. 20, p < .001). This difference in ERG score was not observed in black biopsy group (29 vs.32, p = 0.84). The combination of ERG and PCA3 score had a significant increased 15% of AUC as compared to serum PSA alone (0.68 vs. 0.53, p = 0.0062) for predicting CaP in white men. In contrast, the biomarker panel performed more poorly than serum PSA alone in black patients (AUC = 0.49 vs. 0.61, p = 0.0770). CONCLUSIONS Post-DRE urine ERG and PCA3 mRNA expression levels were identified as novel and informative markers for increasing the PA for CaP diagnosis among white men. This panel, in combination with race/ethnicity and PSA, may provide an opportunity to help patients and physicians make informed decisions about early detection, biopsy, and management of prostate cancer. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e923 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Yongmei Chen More articles by this author Jennifer Cullen More articles by this author Aminia Ali More articles by this author David G. McLeod More articles by this author Shiv Srivastava More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...