MP78-04 INFLUENCE OF RADICAL PROSTATECTOMY ON SERUM BIOAVAILABLE TESTOSTERONE LEVEL IN JAPANESE PATIENTS WITH LOCALIZED PROSTATE CANCER: A LONGITUDINAL STUDY

Abstract

You have accessJournal of UrologyProstate Cancer: Localized VIII1 Apr 2015MP78-04 INFLUENCE OF RADICAL PROSTATECTOMY ON SERUM BIOAVAILABLE TESTOSTERONE LEVEL IN JAPANESE PATIENTS WITH LOCALIZED PROSTATE CANCER: A LONGITUDINAL STUDY Shoichiro Iwatsuki, Shoichi Sasaki, Yasue Kubota, Hiroki Kubota, Hiroyuki Kamiya, Yukihiro Umemoto, and Kenjiro Kohri Shoichiro IwatsukiShoichiro Iwatsuki More articles by this author , Shoichi SasakiShoichi Sasaki More articles by this author , Yasue KubotaYasue Kubota More articles by this author , Hiroki KubotaHiroki Kubota More articles by this author , Hiroyuki KamiyaHiroyuki Kamiya More articles by this author , Yukihiro UmemotoYukihiro Umemoto More articles by this author , and Kenjiro KohriKenjiro Kohri More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2820AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES It is widely accepted that prostate cancer (PCa) is affected by serum testosterone (T). Interestingly, several authors have reported that serum total testosterone (TT) level had elevated after radical prostatectomy. However, TT consists of free testosterone, albumin-bound T, and sex hormone binding globulin (SHBG)-bound T. Only free T and albumin-bound T have biological activity (bioavailable T). However, the change of T activity before and after prostatectomy is unknown. In this study, we longitudinally measured serum bioavailable T levels before and after radical prostatectomy and evaluated the effect of prostatectomy on serum T activity. METHODS A total of 262 patients with prostate cancer who underwent robot-assisted laparoscopic prostatectomy (RALP) between May 2011 and April 2014 were enrolled in this study. Patients who received hormonal therapy during the observation period were excluded. Serum luteinizing hormone (LH), TT, and SHBG were measured before and 1 and 3 months after operation. Bioavailable T levels were calculated according to the ISSAM webpage (www.issam.ch/freetesto.htm) (abbreviated as cBAT). RESULTS Serum LH, TT, SHBG, and cBAT before and 1 and 3 months after radical prostatectomy are shown in the Table. Serum LH, TT, and cBAT levels were significantly increased both 1 and 3 months after operation (paired t-test). Postoperative serum SHBG level was also significantly higher than the preoperative value (paired t-test). There were no significant correlations between the rate of increase of hormone value and patients' age, prostatic volume, and the severity of prostate cancer (Pearson□fs correlation coefficient). CONCLUSIONS This study clarified that not only LH and TT but also bioavailable T significantly increase after radical prostatectomy in patients with PCa. Because this increased testosterone activity may affect postoperative PCa, postoperative monitoring of serum T activity should be performed, especially in patients in whom the resection margin is positive. preoperative postoperative 1 month (p value) postoperative 3 months (p value) LH [mIU/mL] 5.4 ± 3.2 6.4 ± 3.4 (< 10^-12) 6.3 ± 3.4 (< 10^-10) TT [ng/mL] 4.01 ± 1.39 4.37 ± 1.44 (< 10^-7) 4.33 ± 1.39 (< 10^-5) cBAT [ng/mL] 1.29 ± 0.41 1.34 ± 0.38 (< 0.05) 1.36 ± 0.39 (< 0.01) SHBG [nmol/L] 61.2 ± 23.2 64.7 ± 23.9 (< 0.05) 64.3 ± 26.8 (< 0.05) © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e1003 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shoichiro Iwatsuki More articles by this author Shoichi Sasaki More articles by this author Yasue Kubota More articles by this author Hiroki Kubota More articles by this author Hiroyuki Kamiya More articles by this author Yukihiro Umemoto More articles by this author Kenjiro Kohri More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...