MP78-18 THE RELATIONSHIP BETWEEN PREOPERATIVE C - REACTIVE PROTEIN AND FUHRMAN NUCLEAR GRADE IN STAGE T1 RENAL CELL CARCINOMA

Abstract

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging II1 Apr 2016MP78-18 THE RELATIONSHIP BETWEEN PREOPERATIVE C - REACTIVE PROTEIN AND FUHRMAN NUCLEAR GRADE IN STAGE T1 RENAL CELL CARCINOMA Rishi Sekar, Dattatraya Patil, Jeffrey Pearl, Yoram Baum, Stephanie Spetka, Meherdad Alemozaffar, Christopher Filson, John Pattaras, Kenneth Ogan, and Viraj Master Rishi SekarRishi Sekar More articles by this author , Dattatraya PatilDattatraya Patil More articles by this author , Jeffrey PearlJeffrey Pearl More articles by this author , Yoram BaumYoram Baum More articles by this author , Stephanie SpetkaStephanie Spetka More articles by this author , Meherdad AlemozaffarMeherdad Alemozaffar More articles by this author , Christopher FilsonChristopher Filson More articles by this author , John PattarasJohn Pattaras More articles by this author , Kenneth OganKenneth Ogan More articles by this author , and Viraj MasterViraj Master More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1974AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In an era of active surveillance for small renal masses (SRMs), non-invasive predictors of tumor aggressiveness may be helpful in identifying high-risk patients for surgical intervention. In this study, we evaluate the predictive value of preoperative C-reactive protein (CRP) on Furhman Nuclear Grade (FNG) in patients with stage T1 renal cell carcinoma (RCC). METHODS Patients who underwent nephrectomy for stage T1 RCC with documented preoperative CRP within 15 days prior to the surgery were included in the study. Surgical pathology reports were used to determine TNM stage and FNG. Receiver operating characteristic (ROC) analysis, sensitivity-specificity analysis, and Youden index were used to determine the optimal threshold of preoperative CRP in predicting FNG 4 disease versus FNG 1-3 disease. Logistic regression analysis was then performed to assess the significance and independence of preoperative CRP in predicting FNG 4 disease. RESULTS 351 patients were included in the study. On ROC analysis, area under the curve (AUC) was 0.7576. The optimal threshold of preoperative CRP was found to be 4.8 mg/dL. On multivariate logistic regression, CRP≥4.8 mg/dL was found to be a significant and independent predictor of FNG 4 disease (OR 9.9, 95%CI: 1.95-51.7, p=0.006) while adjusting for age, gender, race, BMI. CONCLUSIONS Our data show that preoperative CRP≥4.8 mg/dL is a significant and independent predictor of FNG 4 disease in patients with stage T1 RCC. These findings suggest that a standardized, cost-effective, and non-invasive preoperative laboratory value can provide crucial prognostic information in patients undergoing active surveillance for SRMs, allowing for improved patient selection for definitive surgical therapy. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1033 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Rishi Sekar More articles by this author Dattatraya Patil More articles by this author Jeffrey Pearl More articles by this author Yoram Baum More articles by this author Stephanie Spetka More articles by this author Meherdad Alemozaffar More articles by this author Christopher Filson More articles by this author John Pattaras More articles by this author Kenneth Ogan More articles by this author Viraj Master More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...