MP78-10 THE INFLUENCE OF GENETIC VARIANTS ON CLINICAL OUTCOMES AND TOXIC EFFECTS IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA TREATED WITH SORAFENIB: A MULTI-CENTER RESEARCH

Abstract

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging II1 Apr 2016MP78-10 THE INFLUENCE OF GENETIC VARIANTS ON CLINICAL OUTCOMES AND TOXIC EFFECTS IN PATIENTS WITH ADVANCED RENAL CELL CARCINOMA TREATED WITH SORAFENIB: A MULTI-CENTER RESEARCH chao qin, qiang cao, pu li, shangqian wang, jian wang, meilin wang, liqun zhou, dingwei ye, yiran huang, xiaofeng sun, qing zou, lijiang sun, jian zhu, fade liu, li cui, xiaoxiang wang, hu zhao, jianchun chen, zhengdong zhang, pengfei shao, xiaobing ju, and changjun yin chao qinchao qin More articles by this author , qiang caoqiang cao More articles by this author , pu lipu li More articles by this author , shangqian wangshangqian wang More articles by this author , jian wangjian wang More articles by this author , meilin wangmeilin wang More articles by this author , liqun zhouliqun zhou More articles by this author , dingwei yedingwei ye More articles by this author , yiran huangyiran huang More articles by this author , xiaofeng sunxiaofeng sun More articles by this author , qing zouqing zou More articles by this author , lijiang sunlijiang sun More articles by this author , jian zhujian zhu More articles by this author , fade liufade liu More articles by this author , li cuili cui More articles by this author , xiaoxiang wangxiaoxiang wang More articles by this author , hu zhaohu zhao More articles by this author , jianchun chenjianchun chen More articles by this author , zhengdong zhangzhengdong zhang More articles by this author , pengfei shaopengfei shao More articles by this author , xiaobing juxiaobing ju More articles by this author , and changjun yinchangjun yin More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1966AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Polymorphisms in genes associated with pharmacokinetics and pharmacodynamics may affect the treatment efficacy of certain kinase inhibitors. The purpose of the present study was to investigate whether genetic variants that influence angiogenesis and sorafenib pharmacokinetics are associated with clinical outcomes and toxic effects in advanced renal cell carcinoma patients treated with this drug. METHODS One hundred patients with advanced renal cell carcinoma were enrolled. Forty-two polymorphisms in 15 genes were selected for genotyping and analyzed for associations with progression-free survival, overall survival, and toxic effects. RESULTS We found that rs1570360 in VEGF and rs2239702 in VEGFR2 were significantly associated with progression-free survival (log-rank P = 0.032 and 0.031, respectively). Specifically, patients carrying the variant genotypes (AG+AA) of these two polymorphisms both had an unfavorable progression-free survival (rs1570360, HR = 1.78, 95% CI = 1.04-3.12; rs2239702, HR = 2.01, 95% CI = 1.18-3.43). In addition, compared with those with the rs2239702 GG genotype, patients with the AG+AA genotype suffered an unfavorable OS (HR = 1.85, 95% CI = 1.02-3.36). We found that the VEGF rs2010963 CG+GG genotypes had a significantly increased risk of hand-foot syndrome (OR = 10.32, 95% CI = 2.67-40.03), and the ABCB1 rs1045642 CT+TT genotypes had an increased risk of high blood pressure (OR = 4.00, 95% CI = 1.09-14.67). CONCLUSIONS Our results suggest that polymorphisms in VEGF and VEGFR2 are associated with sorafenib clinical outcomes, and polymorphisms in VEGF and ABCB1 are associated with sorafenib-related toxicities. Larger studies are warranted to validate our findings. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1028-e1029 Advertisement Copyright & Permissions© 2016MetricsAuthor Information chao qin More articles by this author qiang cao More articles by this author pu li More articles by this author shangqian wang More articles by this author jian wang More articles by this author meilin wang More articles by this author liqun zhou More articles by this author dingwei ye More articles by this author yiran huang More articles by this author xiaofeng sun More articles by this author qing zou More articles by this author lijiang sun More articles by this author jian zhu More articles by this author fade liu More articles by this author li cui More articles by this author xiaoxiang wang More articles by this author hu zhao More articles by this author jianchun chen More articles by this author zhengdong zhang More articles by this author pengfei shao More articles by this author xiaobing ju More articles by this author changjun yin More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...