MP78-04 IMPACT OF AN ENSUING DIAGNOSIS OF RENAL CELL CARCINOMA AMONG PATIENTS WHO HAD A PREVIOUS DIAGNOSIS OF A DIFFERENT PRIMARY NEOPLASM

Abstract

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging II1 Apr 2016MP78-04 IMPACT OF AN ENSUING DIAGNOSIS OF RENAL CELL CARCINOMA AMONG PATIENTS WHO HAD A PREVIOUS DIAGNOSIS OF A DIFFERENT PRIMARY NEOPLASM Joel Slaton, Jet Li, Ngoc Quyen T Duong, and Kai Ding Joel SlatonJoel Slaton More articles by this author , Jet LiJet Li More articles by this author , Ngoc Quyen T DuongNgoc Quyen T Duong More articles by this author , and Kai DingKai Ding More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1960AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES With the expanding utilization of abdominal imaging as a cancer surveillance modality after treatment of various primary neoplasms, there is a potential for increased diagnosis of ensuing renal cell carcinomas (RCC). We investigated the effect of a diagnosis of RCC after diagnosis and treatment of a prior primary neoplasm on patient survival. METHODS We interrogated the SEER database to identify all patients with a diagnosis of RCC following a primary malignancy (respiratory [RCa], breast [BCa], colorectal [CRCa], and head and neck [HNCa]) between 1996 and 2012. Patient with prostate cancer were excluded given the more limited use of abdominal imaging in this population. Standardized incidence ratio (SIR) were determined relative to the general RCC population. Distribution of stage of ensuing RCC were compared against those of the general RCC population. The cancer specific surival for both the primary malignancy and the ensuing RCC were determined as well as the overall survival of the patient population and compared against the general population with the primary malignancy and the general RCC population. RESULTS Among the 807,000 patients with one of the four primary neoplasms analyzed, a total of 1902 patient developed RCC at a median 32 mos: 35 mos for HNCa patients, 21 mos for CRCa, 17 mos for RCa and 42 mos for BCa. 0.2% of patients with HNCa developed RCC, 0.4% among those with CRCa, 0.2% among those with RCa, 0.2% among those with BCa. The SIR relative to general population was 2.78 for those with HNCa, 3.57 for those with CRCa, 3.85 for those with RCa and 1.57 for those with BCa. SIR was higher for men than women in nongender related cancer. As might be expected, patients with an ensuing RCC after a primary tumor had a lower SEER stage compared to those presenting with RCC as their initial neoplasm (p<0.001). This favorable stage distribution was reflected in a superior cancer specific survival among those with ensuing RCC versus those presenting with an initial RCC. The development of an ensuing RCC did not impact overall patient survival among patients with any of the primary malignancies. CONCLUSIONS Patients undergoing surveillance after treatment of a primary neoplasm are at increased risk for development of a renal cell neoplasm. However, these tumors appears to have little effect on the overall survival of this high risk patient population. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1025 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Joel Slaton More articles by this author Jet Li More articles by this author Ngoc Quyen T Duong More articles by this author Kai Ding More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...