MP78-02 TRENDS IN NEOADJUVANT CHEMOTHERAPY USE AND ONCOLOGICAL OUTCOMES FOR MUSCLE-INVASIVE BLADDER CANCER IN JAPAN: A MULTICENTER STUDY

Abstract

You have accessJournal of UrologyBladder Cancer: Invasive VI1 Apr 2018MP78-02 TRENDS IN NEOADJUVANT CHEMOTHERAPY USE AND ONCOLOGICAL OUTCOMES FOR MUSCLE-INVASIVE BLADDER CANCER IN JAPAN: A MULTICENTER STUDY Go Anan, Shingo Hatakeyama, Naoki Fujita, Hiromichi Iwamura, Toshikazu Tanaka, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Makoto Sato, and Chikara Ohyama Go AnanGo Anan More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Naoki FujitaNaoki Fujita More articles by this author , Hiromichi IwamuraHiromichi Iwamura More articles by this author , Toshikazu TanakaToshikazu Tanaka More articles by this author , Hayato YamamotoHayato Yamamoto More articles by this author , Yuki TobisawaYuki Tobisawa More articles by this author , Tohru YoneyamaTohru Yoneyama More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Takuya KoieTakuya Koie More articles by this author , Hiroyuki ItoHiroyuki Ito More articles by this author , Kazuaki YoshikawaKazuaki Yoshikawa More articles by this author , Toshiaki KawaguchiToshiaki Kawaguchi More articles by this author , Makoto SatoMakoto Sato More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2550AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Despite benefits of neoadjuvant chemotherapy (NAC), the adoption of guideline recommendations for NAC use in patients with muscle-invasive bladder cancer (MIBC) has been slow. We aimed to evaluate temporal trends in NAC use and oncological outcomes in a representative cohort of patients with MIBC. METHODS We included 532 patients from 4 hospitals who underwent radical cystectomy (RC) for MIBC in 1996-2017. We retrospectively evaluated temporal changes in NAC use and progression-free and overall survival. Candidates for NAC were administered with either cisplatin- or carboplatin-based regimens. The impact of NAC on oncological outcomes was examined using multivariate Cox regression analysis with inverse probability of treatment weighting (IPTW) models. RESULTS Of 532 patients, 336 underwent NAC followed by RC (NAC group) and 196 underwent RC alone (Ctrl group). NAC use significantly increased from 10% (1996-2004) to 83% (2005-2016). The number of patients administered with cisplatin- and carboplatin-based regimens was 43 and 280, respectively. There were no significant differences between PFS and OS when comparing the cisplatin- and carboplatin-based therapies. The number of pT0 and pT3-4 patients was significantly higher and lower in the NAC group than the Ctrl group, respectively. Oncological outcomes in the NAC group were significantly improved compared to those in the Ctrl group in progression-free and overall survival. Multivariable analysis with IPTW models revealed that NAC significantly improved oncological outcomes in patients with MIBC. A nomogram for 5-year overall survival predicted 16% improvement in patients undergoing NAC. CONCLUSIONS NAC use for MIBC increased after 2005. Platinum-based NAC for MIBC potentially improves oncological outcomes. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e1036-e1037 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Go Anan More articles by this author Shingo Hatakeyama More articles by this author Naoki Fujita More articles by this author Hiromichi Iwamura More articles by this author Toshikazu Tanaka More articles by this author Hayato Yamamoto More articles by this author Yuki Tobisawa More articles by this author Tohru Yoneyama More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Takuya Koie More articles by this author Hiroyuki Ito More articles by this author Kazuaki Yoshikawa More articles by this author Toshiaki Kawaguchi More articles by this author Makoto Sato More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...