MP77-12 A PHASE 2 CLINICAL TRIAL EVALUATING THE PREVENTIVE EFFICACY OF LACTOBACILLUS VAGINAL SUPPOSITORIES IN WOMEN WITH RECURRENT CYSTITIS

Abstract

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder II (MP77)1 Apr 2020MP77-12 A PHASE 2 CLINICAL TRIAL EVALUATING THE PREVENTIVE EFFICACY OF LACTOBACILLUS VAGINAL SUPPOSITORIES IN WOMEN WITH RECURRENT CYSTITIS Takuya Sadahira*, Koichiro Wada, Ayano Ishii, Motoo Araki, Toyohiko Watanabe, and Yasutomo Nasu Takuya Sadahira*Takuya Sadahira* More articles by this author , Koichiro WadaKoichiro Wada More articles by this author , Ayano IshiiAyano Ishii More articles by this author , Motoo ArakiMotoo Araki More articles by this author , Toyohiko WatanabeToyohiko Watanabe More articles by this author , and Yasutomo NasuYasutomo Nasu More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000963.012AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Recurrent cystitis is very common amongst women, and alternative to antibacterial prophylaxis is necessary. This study evaluate the efficacy and safety of Lactobacillus vaginal suppositories for preventing recurrent cystitis. METHODS: This was prospective phase 2 clinical trial. Subjects received vaginal suppositories containing the GAI 98322 strain of Lactobacillus crispatus every 2 days or 3 times a week for one year. The primary endpoint is recurrence of cystitis, and we analyzed the total number of recurrent cystitis episodes before and after the start of treatment with Lactobacillus vaginal suppositories. The secondary endpoints are adverse events. RESULTS: A total of 28 women were enrolled, and 22 completed the study. There was a 44% reduction in episode of cystitis for one year during the treatment of Lactobacillus vaginal suppositories (5.36 vs 2.36, p=0.00015). No treatment-related adverse events ware observed. CONCLUSIONS: The vaginal suppositories containing the GAI 98322 strain was effective and safe for preventing recurrent cystitis. Lager efficacy trials of this new preventive methods for recurrent cystitis are warranted. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1168-e1168 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Takuya Sadahira* More articles by this author Koichiro Wada More articles by this author Ayano Ishii More articles by this author Motoo Araki More articles by this author Toyohiko Watanabe More articles by this author Yasutomo Nasu More articles by this author Expand All Advertisement PDF downloadLoading ...