MP77-05 LOW AMPLITUDE RHYTHMIC CONTRACTIONS INFLUENCE SENSATIONS OF URGENCY IN PATIENTS WITH OVERACTIVE BLADDER SYNDROME

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction II1 Apr 2016MP77-05 LOW AMPLITUDE RHYTHMIC CONTRACTIONS INFLUENCE SENSATIONS OF URGENCY IN PATIENTS WITH OVERACTIVE BLADDER SYNDROME Andrew Colhoun, Adam Klausner, MaryEllen Dolat, Eugene Bell, Anna Nagle, Paul Ratz, Robert Barbee, and John Speich Andrew ColhounAndrew Colhoun More articles by this author , Adam KlausnerAdam Klausner More articles by this author , MaryEllen DolatMaryEllen Dolat More articles by this author , Eugene BellEugene Bell More articles by this author , Anna NagleAnna Nagle More articles by this author , Paul RatzPaul Ratz More articles by this author , Robert BarbeeRobert Barbee More articles by this author , and John SpeichJohn Speich More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1919AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Low amplitude rhythmic contractions (LARC), visualized as phasic intravesical pressure (pves) changes, are commonly seen during urodynamics (UD). A significant rise in pves will increase bladder wall tension and can elicit an increase in sensation. LARC are dampened by the viscoelasticity of the bladder, and not all elevations in bladder wall tension are expected to be sufficient to cause an increase in sensation. This study aims to determine thresholds for pves amplitude elevations that trigger patient-reported changes in sensation during filling. METHODS As part of an IRB-approved urodynamics (UD) protocol, patients with overactive bladder syndrome (OAB), defined as ICIq-OAB question 5a = 3, underwent standard UD testing and simultaneously used a real-time sensation meter to record continuous changes in sensation from 0-100% during filling. Patients were instructed on use of the meter prior to the study. Sensation values were time-linked to pves. Normalized pves was differentiated to identify inflection points, and baseline pves was calculated via polynomial regression (Figure 1). Significant elevation in pves from baseline was defined as = 5% normalized value, while any elevation in patient-reported sensation (values sampled every 10 sec) was considered significant. Significant phasic rises in pves were juxtaposed to sensation changes to determine if pves and sensation events coincided. RESULTS Twelve patients underwent UD with use of the sensation meter – 3 were excluded (transducer error, fill to 30mL, only 10% sensation reached). Average phasic pves and sensation change event frequencies during filling were similar: 2.0±0.2 & 2.1±0.3 cycles/min, respectively (p=0.9). Of sensation changes, 53±8% were within 10 sec of significant pves elevations (average ?pves = 20±3% normalized minimum). CONCLUSIONS The frequency of changes in patient-reported sensation during filling correspond with phasic pves elevations, generated by LARC. Further refinement of sensation thresholds may allow development of non-invasive techniques to better characterize a LARC-mediated subtype of OAB. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1017 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Andrew Colhoun More articles by this author Adam Klausner More articles by this author MaryEllen Dolat More articles by this author Eugene Bell More articles by this author Anna Nagle More articles by this author Paul Ratz More articles by this author Robert Barbee More articles by this author John Speich More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...