MP76-10 TEMPORAL TRENDS IN THE INCIDENCE OF TESTICULAR CANCER IN THE UNITED STATES OVER THE PAST FOUR DECADES

Abstract

You have accessJournal of UrologyPenile & Testicular Cancer: Penile & Testicular Cancer III (MP76)1 Apr 2020MP76-10 TEMPORAL TRENDS IN THE INCIDENCE OF TESTICULAR CANCER IN THE UNITED STATES OVER THE PAST FOUR DECADES Stephen W. Reese*, Karl H. Tully Herne, Junaid Nabi, Marco Paciotti, Eugene B. Cone, Stuart R. Lipsitz, and Quoc-Dien Trinh Stephen W. Reese*Stephen W. Reese* More articles by this author , Karl H. Tully HerneKarl H. Tully Herne More articles by this author , Junaid NabiJunaid Nabi More articles by this author , Marco PaciottiMarco Paciotti More articles by this author , Eugene B. ConeEugene B. Cone More articles by this author , Stuart R. LipsitzStuart R. Lipsitz More articles by this author , and Quoc-Dien TrinhQuoc-Dien Trinh More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000962.010AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Testicular cancer is the most commonly diagnosed solid-organ neoplasm in young men, with differences in incidence across racial groups. Testicular cancer incidence has increased since the 1970s, most notable in white men. However trends in testicular cancer remain unknown since the early 2000s. Thus, we investigated age-adjusted incidence rates of testicular cancer, from 1975 to 2015, using SEER data to further understand temporal trends and drivers of disease. METHODS: We queried the Surveillance, Epidemiology and End Results (SEER) database to examine individuals aged 20-45 diagnosed with testicular cancer between 1975-2015 in the nine original SEER registries. We also performed sub-analyses according to stage at presentation and race. Average annual percentage change (AAPC) and 95% CI were calculated to examine changes over time using SEER*Stat Software. RESULTS: 23,560 men were diagnosed with testicular cancer in our study. Most patients had localized disease (68.5%). We observed a significant increase in localized disease over the last four decades, from 7.2 per 100,000 men in 1975 to 11.9 per 100,000 men in 2015 (AAPC 2.0*, 95% CI 1.5-2.5). White patients demonstrated the highest incidence (Range: 3.8 - 11.3/100,000 men) and the largest increase-in-incidence rates (AAPC 2.1*, 95%CI 1.5-2.7). The lowest incidence was observed in black men (AAPC 1.3*, 95% CI: 0.1-2.4). The incidence in white men has plateaued since 2002 (AAPC -0.3, -1.3-0.8), while incidence rates in black men (AAPC 1.3*, 95%CI 0.1-2.4) and men of other races (AAPC 1.9*, 95%CI 1.1-2.7) have increased at the same rate as before 2002 (Figure 2). [* statistically significant, p < 0.05]. CONCLUSIONS: We observed a significant increase in incidence of testicular cancer over the last four decades. Etiologies for increasing rates of testicular cancer and for racial differences in the incidence of testicular cancer remain unclear, however warrant further investigation. Source of Funding: None. © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1155-e1155 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Stephen W. Reese* More articles by this author Karl H. Tully Herne More articles by this author Junaid Nabi More articles by this author Marco Paciotti More articles by this author Eugene B. Cone More articles by this author Stuart R. Lipsitz More articles by this author Quoc-Dien Trinh More articles by this author Expand All Advertisement PDF downloadLoading ...