MP76-03 OPTIMAL TREATMENT STRATEGY FOR PARATESTICULAR LIPOSARCOMA

Abstract

You have accessJournal of UrologyPenile & Testicular Cancer: Penile & Testicular Cancer III (MP76)1 Apr 2020MP76-03 OPTIMAL TREATMENT STRATEGY FOR PARATESTICULAR LIPOSARCOMA Rei Kamitani*, Kazuhiro Matsumoto, Yota Yasumizu, Nobuyuki Tanaka, Toshikazu Takeda, Shinya Morita, Takeo Kosaka, Ryuichi Mizuno, Hiroshi Asanuma, and Mototsugu Oya Tokyo, Japan Rei Kamitani*Rei Kamitani* More articles by this author , Kazuhiro MatsumotoKazuhiro Matsumoto More articles by this author , Yota YasumizuYota Yasumizu More articles by this author , Nobuyuki TanakaNobuyuki Tanaka More articles by this author , Toshikazu TakedaToshikazu Takeda More articles by this author , Shinya MoritaShinya Morita More articles by this author , Takeo KosakaTakeo Kosaka More articles by this author , Ryuichi MizunoRyuichi Mizuno More articles by this author , Hiroshi AsanumaHiroshi Asanuma More articles by this author , and Mototsugu Oya Tokyo, JapanMototsugu Oya Tokyo, Japan More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000962.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Liposarcoma is one of the most common subtypes of soft tissue sarcoma. The tumor often develops in the lower extremities and the retroperitoneal or paratesticular region. The standard treatment for localized liposarcoma is surgical resection with negative margins. However, there are no guidelines for paratesticular liposarcoma due to its rarity. The effects of high inguinal orchiectomy and adjuvant radiation therapy (RT) have not yet been quantitatively evaluated. METHODS: A systematic Medline and Google search was performed to identify articles describing localized paratesticular liposarcoma published between 1979 and 2018 in English. The final cohort included 261 patients in 173 articles. The starting point was the time of surgical treatment, and the endpoint was the time of recurrence, local recurrence or distant metastasis. RESULTS: The average age was 59.9 years (range 15-89), and the average tumor size was 11.0 cm (range 0.4-55). One hundred and seventy-three patients underwent high inguinal orchiectomy, and 28 underwent only tumor resection. Based on the Kaplan-Meier curves, recurrence-free survival rates were significantly higher in those who underwent high inguinal orchiectomy than in those who underwent tumorectomy (p<0.001) (Figure 1a). Moreover, those with microscopic positive margins had a higher risk of recurrence than those with negative margins (p<0.001). In contrast, adjuvant RT after resection had no significant effect on recurrence-free survival, even in subgroup analysis of patients with positive margins. Regarding the pathological subtypes, dedifferentiated, pleomorphic and round cell liposarcoma had a higher risk of recurrence than well-differentiated or myxoid liposarcoma (Figure 1b). In the multivariate analysis, high inguinal orchiectomy greatly affected recurrence-free survival (hazard ratio 0.04, p<0.001). Furthermore, the tumor size (hazard ratio 1.11, p=0.04), and dedifferentiated and round cell subtypes (hazard ratio 30.8, p=0.002 and hazard ratio 29.7, p=0.02, respectively) are independent risk factors for recurrence. CONCLUSIONS: Our study revealed complete resection with high inguinal orchiectomy to be a satisfactory surgical approach for paratesticular liposarcoma. However, the effects of adjuvant RT remain unclear. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1152-e1152 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rei Kamitani* More articles by this author Kazuhiro Matsumoto More articles by this author Yota Yasumizu More articles by this author Nobuyuki Tanaka More articles by this author Toshikazu Takeda More articles by this author Shinya Morita More articles by this author Takeo Kosaka More articles by this author Ryuichi Mizuno More articles by this author Hiroshi Asanuma More articles by this author Mototsugu Oya Tokyo, Japan More articles by this author Expand All Advertisement PDF downloadLoading ...