MP76-03 CORRELATION OF ERECTILE FUNCTION REHABILITATION WITH PRESERVATION OF NOCTURNAL PENILE TUMESCENSE 6 WEEKS AFTER NERVE-SPARING RADICAL PROSTATECTOMY – EFFECT OF DAILY LOW-DOSE SILDENAFIL

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy I1 Apr 2016MP76-03 CORRELATION OF ERECTILE FUNCTION REHABILITATION WITH PRESERVATION OF NOCTURNAL PENILE TUMESCENSE 6 WEEKS AFTER NERVE-SPARING RADICAL PROSTATECTOMY – EFFECT OF DAILY LOW-DOSE SILDENAFIL Andreas Bannowsky, Stefan Ückert, Daniar Osmonov, and Klaus-Peter Jünemann Andreas BannowskyAndreas Bannowsky More articles by this author , Stefan ÜckertStefan Ückert More articles by this author , Daniar OsmonovDaniar Osmonov More articles by this author , and Klaus-Peter JünemannKlaus-Peter Jünemann More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1854AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Previous studies showed that daily low dose sildenafil leads to improvement of the preservation of nocturnal penile tumescense and rigidity (NPTR) 6 weeks after nerve-sparing radical prostatectomy (nsRP). Aim of this study was the evaluation of NPTR-preservation on further erectile function (EF) recovery. METHODS 24 sexual active patients were operated by nerve-sparing retropubic radical prostatectomy. An erectometer measurement of NPTR (Rigi-Scan®) was carried out on each patient after removal of the transurethral catheter and again 6 weeks after surgery. To maintain and support recovery of spontaneous erectile function 12 patients with preserved nocturnal erections detected during NPTR-recordings received sildenafil 25mg/d at night starting immediately one the day after catheter removal (group 1). A control of 12 patients underwent follow up without daily PDE-5-inhibitors (group 2). All patients completed an IIEF-5 questionnaire concerning erectile function preoperatively, 3, 6, and 12 months after surgery. RESULTS Group 1 (daily 25mg sildenafil) showed 2-5 erections (mean 3.2 erections/night) during the first night after catheter removal. In the control (group 2) 1-5 erections (mean 3.1 erections/night) were recorded within this acute phase after nsRP. NPTR-recordings 6 weeks after nsRP showed a decline of nocturnal penile erections with only a slight decrease in group 1 (1-4 erections/night, mean 2.8 erections) vs. group 2 (0-2 erections/night, mean 1.1 erections/night) (p<0.05). In the group of daily sildenafil the IIEF-5 score decreased from preoperative 22.4 mean score to 3.8 at 3 months, 12.4 at 6 months and 17.5 at 12 months after nsRP. In the control group preoperative IIEF-5 mean score 23.2 decreased to 2.6 at 3 months, 7.4 at 6 months, 9.3 at 12 months. Statistical evaluation showed a correlation of NPTR-preservation with a significant increase of IIEF-5 score and time to recovery of erectile function (p<0.05). CONCLUSIONS EF rehabilitation with daily low dose sildenafil leads to significant preservation of nocturnal penile tumescense 6 weeks after nsRP which is correlated with a significant increase of erectile function recovery. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1007 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Andreas Bannowsky More articles by this author Stefan Ückert More articles by this author Daniar Osmonov More articles by this author Klaus-Peter Jünemann More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...