MP76-17 ASSOCIATIONS OF PRE-ORCHIECTOMY HORMONE LEVELS TO TESTICULAR GERM CELL TUMOR PATHOLOGY, CLINICAL STAGE, AND SIZE

Abstract

You have accessJournal of UrologyPenile & Testicular Cancer: Penile & Testicular Cancer III (MP76)1 Apr 2020MP76-17 ASSOCIATIONS OF PRE-ORCHIECTOMY HORMONE LEVELS TO TESTICULAR GERM CELL TUMOR PATHOLOGY, CLINICAL STAGE, AND SIZE Kevin Pineault*, Joseph Cheaib, Amin Herati, and Phillip Pierorazio Kevin Pineault*Kevin Pineault* More articles by this author , Joseph CheaibJoseph Cheaib More articles by this author , Amin HeratiAmin Herati More articles by this author , and Phillip PierorazioPhillip Pierorazio More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000962.017AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To investigate the relationship between pre-orchiectomy hormones and pathology, clinical stage, and tumor size among patients with testicular germ cell tumors (GCTs). METHODS: An institutional testicular cancer database was reviewed for all patients from 2013 to 2018 older than 18 years that had an orchiectomy performed. Per routine at our institution, testosterone panel, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and estradiol are ordered at index visit for presence of hypogonadism symptoms. RESULTS: 52 patients (median age 31 years (IQR 27-36)), 80.4% white, 48.1% pure seminoma tumor pathology) met study criteria. High estradiol (>50 pg/mL) was significantly associated with non-seminomatous tumor pathology (p=0.01). Patients with elevated pre-orchiectomy levels of FSH (>7.6mIU/mL) and LH (>11.2mIU/mL) were associated with significantly larger mean tumor size (p=0.02 and p=0.05, respectively). The odds of having a non-seminoma were 16 times higher in patients with elevated pre-orchiectomy estradiol levels compared to those with normal levels (OR=16, p=0.02, 95% CI 1.6, 55.8). CONCLUSIONS: These data suggest high pre-orchiectomy estradiol levels were associated with and may predict non-seminomatous tumor pathology. Furthermore, LH and FSH were associated with tumor size. Therefore, knowing the associations between hormone levels before orchiectomy and GCT pathology and size may better personalize management strategies. Future research will evaluate the role of pre-orchiectomy hormone levels and subsequent development of hypogonadism. Source of Funding: No sources of funding were used. © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1159-e1159 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kevin Pineault* More articles by this author Joseph Cheaib More articles by this author Amin Herati More articles by this author Phillip Pierorazio More articles by this author Expand All Advertisement PDF downloadLoading ...