MP76-11 EFFECTS OF 8-YEAR TREATMENT OF LONG-ACTING TESTOSTERONE UNDECANOATE ON METABOLIC PARAMETER, URINARY SYMPTOMS, BONE MINERAL DENSITY AND SEXUAL FUNCTION IN MEN WITH LATE ONSET HYPOGONADISM

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy I1 Apr 2016MP76-11 EFFECTS OF 8-YEAR TREATMENT OF LONG-ACTING TESTOSTERONE UNDECANOATE ON METABOLIC PARAMETER, URINARY SYMPTOMS, BONE MINERAL DENSITY AND SEXUAL FUNCTION IN MEN WITH LATE ONSET HYPOGONADISM Sompol Permpongkosol, Kalayanee Khupulsup, Supatra Leelaphiwat, Sarawan Pavavattananusorn, and Tanoon Pettong Sompol PermpongkosolSompol Permpongkosol More articles by this author , Kalayanee KhupulsupKalayanee Khupulsup More articles by this author , Supatra LeelaphiwatSupatra Leelaphiwat More articles by this author , Sarawan PavavattananusornSarawan Pavavattananusorn More articles by this author , and Tanoon PettongTanoon Pettong More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1862AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The long term effects of long acting testosterone undecanoate (TU) and the CAG repeats Length in a large number of Thai late onset hypogonadism (LOH) men has not yet been reported. This study analyzed the 8-year follow-up effects of intramuscular TU therapy on metabolic parameter, urinary symptoms, bone mineral density, sexual function and investigate the CAG repeats Length in LOH men. METHODS We reviewed the medical records of 428 men with a diagnosis of LOH and who had been treated with TU between January 2007 and December 2014. A total of 4 patients were diagnosed with prostate cancer during TU. There are 120 patients (mean age 65.6 ± 8.9) who had a minimum of 5 years continuous TU supplementation and sufficiently completed records to all analysis and a maximum duration of 8 years. The mean and median duration of treatment was 80.13 and 84 months, respectively. Men received intramuscular injections of 1,000 mg TU at day 1, at week 6, and every 10-14 weeks thereafter. Genomic DNA was extracted from peripheral blood and the CAG repeat region was amplified by PCR. Fragment analysis and sequencings was performed. We confirmed the results with electropherogram and chromatogram (gene scan). The main outcome measure was dynamic parameters changes in testosterone supplement. Statistical analysis were performed with the statistics programs Stata version 14.0 and SPSS11.5. RESULTS TU did not improve all obesity parameter. A statistically significant decline (p < 0.05) was found in waist circumference, % body fat, HbA1c, cholesterol, and LDL. TU did not produce differences in BMI, HDL, triglyceride and the Aging Male Symptoms (AMS) score from the base line. However, a statistically significant increase (p < 0.05) was demonstrated in the level of testosterone, PSA, hematocrit and International index of erectile function score. Both vertebral and femoral BMD was statistically significant increase (p < 0.05). No prostate cancer was reported in this group. The repeat length CAG was between 14-31. The most CAG length was median (20-23) with low testosterone. Men with longer CAG receptor had higher levels of total T and AMS score. There was no association between repeat length and any of the anthropometric measure. CONCLUSIONS Long-term TU treatment in LOH men for up to 8 years durations appears to be safe, tolerable and effective in improving obesity parameter. The results suggested the AR CAG repeat length correlates with serum Testosterone of aging men. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e1011 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Sompol Permpongkosol More articles by this author Kalayanee Khupulsup More articles by this author Supatra Leelaphiwat More articles by this author Sarawan Pavavattananusorn More articles by this author Tanoon Pettong More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...