MP76-05 LENGTH OF INFERTILITY AFFECTS SEMINAL PARAMETERS - FINDINGS OF A CROSS-SECTIONAL SURVEY IN WHITE-EUROPEAN MEN PRESENTING FOR PRIMARY COUPLE'S INFERTILITY

Abstract

You have accessJournal of UrologyInfertility: Basic Research, Physiology, Pathophysiology1 Apr 2015MP76-05 LENGTH OF INFERTILITY AFFECTS SEMINAL PARAMETERS - FINDINGS OF A CROSS-SECTIONAL SURVEY IN WHITE-EUROPEAN MEN PRESENTING FOR PRIMARY COUPLE'S INFERTILITY Eugenio Ventimiglia, Luca Boeri, Paolo Capogrosso, Giovanni La Croce, Alessandro Serino, Giulia Castagna, Angela Pecoraro, Marco Paciotti, Roberta Scano, Alberto Briganti, Francesco Cantiello, Rocco Damiano, Francesco Montorsi, and Andrea Salonia Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Luca BoeriLuca Boeri More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Giovanni La CroceGiovanni La Croce More articles by this author , Alessandro SerinoAlessandro Serino More articles by this author , Giulia CastagnaGiulia Castagna More articles by this author , Angela PecoraroAngela Pecoraro More articles by this author , Marco PaciottiMarco Paciotti More articles by this author , Roberta ScanoRoberta Scano More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Francesco CantielloFrancesco Cantiello More articles by this author , Rocco DamianoRocco Damiano More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2790AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Lifestyle changes and pregnancy postponement, with advances in reproductive technology allowing older individuals to consider having children, support the demographic finding that men are more frequently experiencing fatherhood in late adulthood. We assessed if a delay in seeking reproductive medical help [defined as length of a couple's infertility (LI) at first presentation] may negatively impact over male reproductive function. METHODS Complete data from 1132 men seeking medical help for primary couple's infertility from 2003 to 2013 were analyzed. Primary infertility was defined according to the WHO definition criteria. Complete reproductive history was recorded in order to assess LI. Comorbidities were scored with the Charlson Comorbidity Index (CCI; categorized 0 vs 1 vs ≥2). Testicular volume (TV) was assessed with a Prader orchidometer. Semen analysis values were assessed based on 2010 WHO reference criteria. Descriptive statistics and linear regression models tested the impact of LI in terms of seminal features impairment. RESULTS Mean (SD; range) patient age was 36.3 yrs (5.3; 20-62). Throughout the analyzed time frame, patients' age at presentation significantly increased over time (p=0.02) when comparing 2003-2007 with 2008-2013 period, along with patients' education status (p=0.01). LI at first presentation was 28.4 mos (23.5; 12-228); LI significantly decreased throughout the analyzed time frame (F: 2.13; p=0.02). When grouping LI into 12-mo time frames (namely, 0-12, 13-24, 25-36, 37-48, 49-60, >60 mos), patients' (F: 6.59; p<0.001) and partner's age (F: 4.94; p<0.001), along with BMI (F ratio: 6.28; p<0.001) increased over time. Conversely, sperm concentration (F ratio: 3.28; p=0.006), sperm progressive motility (F: 4.49; p<0.001), and TV (F: 3.93; p=0.002) showed a significant decrease. No significant difference was observed in terms of hormonal values and CCI over time. At MVA linear regression, LI emerged as an independent predictor of sperm concentration (Beta: -0.12, p<0.001) and sperm progressive motility (Beta: -0.12, p=0.002), after adjusting for patients' age, educational status and CCI. CONCLUSIONS Current findings showed that LI decreased during the last ten years. In this context, LI accounts for a negative impact on semen parameters of men with primary couple's infertility. This would suggest that a greater public awareness in the field of reproductive difficulties should be promoted. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e985 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Eugenio Ventimiglia More articles by this author Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Giovanni La Croce More articles by this author Alessandro Serino More articles by this author Giulia Castagna More articles by this author Angela Pecoraro More articles by this author Marco Paciotti More articles by this author Roberta Scano More articles by this author Alberto Briganti More articles by this author Francesco Cantiello More articles by this author Rocco Damiano More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...