MP75-14 IN VIVO BIOMECHANICAL PROPERTIES OF HIGH VERSUS LOW WEIGHT MONOFILAMENT POLYPROPYLENE MESHES. DOES THE KNITTING PATTERN MATTERS?

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Female Urology II1 Apr 2014MP75-14 IN VIVO BIOMECHANICAL PROPERTIES OF HIGH VERSUS LOW WEIGHT MONOFILAMENT POLYPROPYLENE MESHES. DOES THE KNITTING PATTERN MATTERS? Miguel Bigosi, Fernando Maeda, Rodrigo Sisncalchi, Ignacio Dal Frabro, Alessandro Prudente, Paulo Palma, and Cassio Riccetto Miguel BigosiMiguel Bigosi More articles by this author , Fernando MaedaFernando Maeda More articles by this author , Rodrigo SisncalchiRodrigo Sisncalchi More articles by this author , Ignacio Dal FrabroIgnacio Dal Frabro More articles by this author , Alessandro PrudenteAlessandro Prudente More articles by this author , Paulo PalmaPaulo Palma More articles by this author , and Cassio RiccettoCassio Riccetto More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2387AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The use of vaginal meshes for vaginal prolapses can improve anatomical results, but there are major concerns related mainly to vaginal exposure, visceral erosion and chronic pain. Additionally, due to the native vaginal elasticity, it is desirable that a prosthesis present smart distensibility in different directions, for accommodation during sexual intercourse, preventing dyspareunia without jeopardizing the anatomical support. Few studies determined in vitro characteristics of heavy weight meshes but none compared low versus heavy weight ones in terms of post implant mechanical behavior. Moreover, different knitting patterns can also change biomechanical performance. This study aimed to evaluate post implant biomechanical properties of heavy-weight (HW) and low-weight (LW) monofilament polypropylene meshes (PP). METHODS An experimental study was performed in 45 adult female Wistar rats, which were divided into 3 groups (15 each) and were randomly implanted with 32x32 mm HW PP (62g/m2), and LW PP (14g/m2). LW PP was tested in orthogonal manner (called LW1 and LW2). All implants were performed at lower abdomen, between hypodermis and abdominal muscular fascia. After 7, 30 and 60 days, the abdominal walls were removed and the fresh samples underwent biomechanical tests by uniaxial force application (TA500 Universal Testing Machine - AMETEK, Inc, UK) until mesh avulsion from the host site. RESULTS It were analyzed the Maximum Load, Deflection to Maximum Load and Stiffness to Maximum Load. Significant differences were observed among the Maximum Loads for each group (F=32,07, p<0,001) and over time (F=14,41, p<0,001). There were no significant differences among the groups regarding the Deflection to Maximum Load (F=0,52, p=0,607). Nevertheless, significant differences were found in Deflection to Maximum Load over the time (F=5,13, p=0,019). Significant difference of Stiffness was observed among the groups (F=7,33, p=0,008) and over time (F=5,27, p=0,019). In the long-term analysis, performed after 60 days, LW1 presented the higher Stiffness, followed by the HW and LW2. So, when tested in orthogonal directions LW PP presented significant differences in Stiffness and Maximum Loads. CONCLUSIONS The final mechanical behavior of PP meshes could be changed by its weight but also by its knitting pattern. Such properties may be useful for making more biocompatible prostheses for vaginal prolapses, with less foreign material, in order to keep sagittal vaginal elasticity while keeping coronal resistance to prevent prolapse recurrence. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e878-e879 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Miguel Bigosi More articles by this author Fernando Maeda More articles by this author Rodrigo Sisncalchi More articles by this author Ignacio Dal Frabro More articles by this author Alessandro Prudente More articles by this author Paulo Palma More articles by this author Cassio Riccetto More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...