MP74-13 DIABETES SEVERITY, DIABETES BIOMARKERS AND LUTS: FINDINGS FROM NHANES

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction I1 Apr 2016MP74-13 DIABETES SEVERITY, DIABETES BIOMARKERS AND LUTS: FINDINGS FROM NHANES Christopher Tam and Bradley Erickson Christopher TamChristopher Tam More articles by this author and Bradley EricksonBradley Erickson More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1710AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Type 2 Diabetes (DM2) has been implicated in the development of numerous conditions, including lower urinary tract symptoms (LUTS). The purpose of this study is to characterize the relationship between the severity of DM2 and presence of LUTS. METHODS The 2005-2008 cycles of the National Health and Nutrition Examination Survey (NHANES) were queried for men who completed both a DM2 and a kidney/prostate questionnaire. Men with LUTS were defined as those experiencing at least 1 out of 3 of the following: nocturia, hesitancy, or incomplete emptying. Men with DM2 were defined as having been diagnosed by a physician and being actively treated. Multivariate logistic regression with sample weighting was performed controlling for age, race, BMI, and smoking status to assess effects of biomarker levels (HgbA1c, fasting glucose), medication use, and surrogates of disease progression on the presence of LUTS. RESULTS Of the 2980 male participants, those with DM2 were more likely to experience at least one LUTS symptom (adjusted OR 1.64, p < 0.0001). In DM2 patients, diabetic retinopathy and frequent visits to a physician were associated with reporting symptoms, but not the DM2 treatment type, fasting glucose, or lifestyle factors such as exercise (Table 1). Work with a non-physician DM2 specialist decreased the risk. HgbA1c correlated with the number of LUTS in the general population, but not in diabetics (Figure 1). CONCLUSIONS Markers of poorly controlled diabetes (retinopathy, more frequent physician visits) were associated with increased prevalence of LUTS in the diabetic population. However, HgbA1c levels in actively treated DM2 patients do not correlate with LUTS, implying that improving HgbA1c levels alone may not reverse DM2 urologic sequelae. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e974 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Christopher Tam More articles by this author Bradley Erickson More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...