MP74-15 THE EFFECT OF EJACULATION FREQUENCY ON SERUM PROSTATE SPESIFIC ANTIGEN LEVEL

Abstract

You have accessJournal of UrologyProstate Cancer: Markers I1 Apr 2014MP74-15 THE EFFECT OF EJACULATION FREQUENCY ON SERUM PROSTATE SPESIFIC ANTIGEN LEVEL Mehmet Karabakan, Serkan Akdemir, Alp Özgür Akdemir, Çetin Volkan Öztekin, Özer Güzel, Cevdet Serkan Gökkaya, and Mesut Çetinkaya Mehmet KarabakanMehmet Karabakan More articles by this author , Serkan AkdemirSerkan Akdemir More articles by this author , Alp Özgür AkdemirAlp Özgür Akdemir More articles by this author , Çetin Volkan ÖztekinÇetin Volkan Öztekin More articles by this author , Özer GüzelÖzer Güzel More articles by this author , Cevdet Serkan GökkayaCevdet Serkan Gökkaya More articles by this author , and Mesut ÇetinkayaMesut Çetinkaya More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2348AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES In addition to benign prostate hyperplasia (BPH) and prostate cancer, a rise in serum prostate specific antigen (PSA) level can be expectedin urologic instrumentations such as cystoscopy and prostate biopsy, and also in infectious conditions such as prostatitis.These conditions elevate serum PSA by destructing the morphology of prostatic cells or by generating defects in the basal membrane that results in the passage of PSA to circulation more than usual. Recent research speculated on the effect of ejeculation on serum PSA level and reached several results different from each other. So the real effect of ejaculation on serum PSA and its physiological mechanism still remains unknown. In the present study, we aimed to evaluate the association between monthly ejaculation frequency and serum PSA level and to detect the chronic effect of ejaculation on PSA. METHODS Between October 2009 and August 2012, in our outpatient urology clinic, 144 menpresenting with lower urinary tract symptomsand aged between 45-72 were enrolled in the study. Patients were classified into 3 groups according to the number of ejaculations in last month: group 1, 0-5; group 2, 6-10; group 3, more than10, respectively. Groups were compared regarding age, free PSA (fPSA) and total PSA (tPSA) levels, international prostate symptom score (IPSS), international index of erectile function (IIEF), prostate volume measured with trans-rectal ultrasound and PSA density (PSA divided by prostate volume). A p value under 0.05 was accepted significant. RESULTS Patients data were given in table 1.The 3 groups were similar regarding age, tPSA, fPSA, IPSS and prostate volume (P >0.05). IIEF score differencesamong 3 groups wereof statistical significance (P <0.05). CONCLUSIONS In the current study, we observed that monthly ejaculation frequency has no effect on serum PSA level. Table 1: Patients data. Group 1 (n: 78) Group 2 ( n:49) Group 3 ( n:17) p value* Age (years) 59.56±2.58 58.53±5.69 55±6.7 0.68 IPSS 13.87±6.29 13.59±6.8 11.18±5.8 0.140 IIEF 18.56±9.65** 25.3±6.61 ** 29.06±1.34 ** <0.001 tPSA (ng/ml) 1.78±2.58 2.14±2.6 3.1± 4.64 0.10 fPSA (ng/ml) 0.49±0.8 0.44±0.33 0.57±0.71 0.826 PSAD 4.13±3.54 5.97±6.73 9.05±12.16 *** 0.04 Prostate volume (cc) 41.56±21.03 35.87±14.49 35.29±11.97 0.379 ∗ Kruskal Wallis Test, ** Significant differences among all 3 groups(P <0.001), *** Significant differencebetween group 1 and 3 (P = 0.004). © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e862 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Mehmet Karabakan More articles by this author Serkan Akdemir More articles by this author Alp Özgür Akdemir More articles by this author Çetin Volkan Öztekin More articles by this author Özer Güzel More articles by this author Cevdet Serkan Gökkaya More articles by this author Mesut Çetinkaya More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...