MP74-08 THE EFFECT OF NOCTURNAL DIURESIS ON BLADDER STORAGE DYSFUNCTION FOR MALE LUTS PATIENTS

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP74-08 THE EFFECT OF NOCTURNAL DIURESIS ON BLADDER STORAGE DYSFUNCTION FOR MALE LUTS PATIENTS Kanako Matsuoka, Kei Yaginuma, Yu Endo, Yuki Harigane, Yuta Matsuoka, Yuki Yoshida, Hitomi Imai, Akifumi Onagi, Seiji Hoshi, Tomoyuki Koguchi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, and Yoshiyuki Kojima Kanako MatsuokaKanako Matsuoka More articles by this author , Kei YaginumaKei Yaginuma More articles by this author , Yu EndoYu Endo More articles by this author , Yuki HariganeYuki Harigane More articles by this author , Yuta MatsuokaYuta Matsuoka More articles by this author , Yuki YoshidaYuki Yoshida More articles by this author , Hitomi ImaiHitomi Imai More articles by this author , Akifumi OnagiAkifumi Onagi More articles by this author , Seiji HoshiSeiji Hoshi More articles by this author , Tomoyuki KoguchiTomoyuki Koguchi More articles by this author , Junya HataJunya Hata More articles by this author , Yuichi SatoYuichi Sato More articles by this author , Hidenori AkaihataHidenori Akaihata More articles by this author , Masao KataokaMasao Kataoka More articles by this author , and Yoshiyuki KojimaYoshiyuki Kojima More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003348.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The causes of nocturia are often discussed separately as nocturnal urine volume and nocturnal bladder capacity problems. Since multiple factors affect nocturia, what affects it most has not been well investigated. We have been studying the bladder storage function as a homeostatic system keeps micturition interval constant by increasing the bladder capacity during the diuretic phase. We hypothesized that nocturnal diuresis could affect nocturnal urine volume and bladder storage function. This study aimed to identify the effect of nocturnal diuresis on bladder storage dysfunction for male patients with lower urinary tract symptoms (LUTS). METHODS: Male LUTS patients who were able to keep 24-h frequency-volume charts (FVCs) for 3 days were included in this study. Patients with residual urine volume greater than 200 mL were excluded. Patients who marked an average of two or more times per night on 3-days 24 h-FVCs were defined as the nocturia (+) group, and those who marked less than two times were defined as the nocturia (-) group. Patient characteristics and parameters of 24-h FVCs were compared between groups, with values of p<0.05 considered significant. RESULTS: The nocturia (+) group (n=52) was significantly older (p=0.01), had a higher nocturnal diuresis rate (p<0.001), and had a smaller voided volume at night (p=0.01) than the nocturia (-) group (n=48). Multivariate analysis showed that increased nocturnal diuresis rate and decreased nocturnal voided volume were significantly related to nocturia (nocturnal diuresis rate: OR 1.04, p<0.001; decreased nocturnal single voided volume: OR 0.985, p=0.001). Nocturnal diuresis was defined as a ratio of the mean diuretic rate at night to the mean diuretic rate during the day of 0.83 or greater (AUC 0.87, sensitivity 81.1%, specificity 79.2%). 17.6% of patients had nocturia with nocturnal diuresis without nocturnal bladder storage dysfunction (nocturnal voided volume <229.3 mL). Then, they had a significantly higher nocturnal diuresis rate than patients with nocturnal diuresis and nocturnal bladder storage dysfunction (p=0.03). CONCLUSIONS: Nocturnal diuresis is clearly associated with nocturia, but an extreme increase in nocturnal diuresis rate unexpectedly leads to increased nocturnal urine volume. Source of Funding: Nothing © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1072 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kanako Matsuoka More articles by this author Kei Yaginuma More articles by this author Yu Endo More articles by this author Yuki Harigane More articles by this author Yuta Matsuoka More articles by this author Yuki Yoshida More articles by this author Hitomi Imai More articles by this author Akifumi Onagi More articles by this author Seiji Hoshi More articles by this author Tomoyuki Koguchi More articles by this author Junya Hata More articles by this author Yuichi Sato More articles by this author Hidenori Akaihata More articles by this author Masao Kataoka More articles by this author Yoshiyuki Kojima More articles by this author Expand All Advertisement PDF downloadLoading ...