MP74-05 OUTCOMES OF NEOADJUVANT CHEMOHORMONAL THERAPY WITH COMPLETE ANDROGEN BLOCKADE, FOLLOWED BY TREATMENT WITH DOCETAXEL AND ESTRAMUSTINE PHOSPHATE BEFORE RADICAL PROSTATECTOMY IN PATIENTS WITH HIGH-RISK LOCALIZED PROSTATE CANCER: A PROPENSITY-SCORE MATCHING ANALYSIS

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy IV (MP74)1 Apr 2020MP74-05 OUTCOMES OF NEOADJUVANT CHEMOHORMONAL THERAPY WITH COMPLETE ANDROGEN BLOCKADE, FOLLOWED BY TREATMENT WITH DOCETAXEL AND ESTRAMUSTINE PHOSPHATE BEFORE RADICAL PROSTATECTOMY IN PATIENTS WITH HIGH-RISK LOCALIZED PROSTATE CANCER: A PROPENSITY-SCORE MATCHING ANALYSIS Shintaro Narita*, Hiromi Sato, Mizuki Kobayashi, Akane Kikuchi, Taketoshi Nara, Sohei Kanda, Kazuyuki Numakura, Atsushi Koizumi, Ryuhei Yamamoto, Mitsuru Saito, Takamitsu Inoue, Shigeru Satoh, Koji Mitsuzuka, Norihiko Tsuchiya, Chikara Ohyama, Yoichi Arai, Hiroshi Nanjo, and Tomonori Habuchi Shintaro Narita*Shintaro Narita* More articles by this author , Hiromi SatoHiromi Sato More articles by this author , Mizuki KobayashiMizuki Kobayashi More articles by this author , Akane KikuchiAkane Kikuchi More articles by this author , Taketoshi NaraTaketoshi Nara More articles by this author , Sohei KandaSohei Kanda More articles by this author , Kazuyuki NumakuraKazuyuki Numakura More articles by this author , Atsushi KoizumiAtsushi Koizumi More articles by this author , Ryuhei YamamotoRyuhei Yamamoto More articles by this author , Mitsuru SaitoMitsuru Saito More articles by this author , Takamitsu InoueTakamitsu Inoue More articles by this author , Shigeru SatohShigeru Satoh More articles by this author , Koji MitsuzukaKoji Mitsuzuka More articles by this author , Norihiko TsuchiyaNorihiko Tsuchiya More articles by this author , Chikara OhyamaChikara Ohyama More articles by this author , Yoichi AraiYoichi Arai More articles by this author , Hiroshi NanjoHiroshi Nanjo More articles by this author , and Tomonori HabuchiTomonori Habuchi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000960.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To investigate the clinical outcomes in patients with high-risk prostate cancer (PCa) treated with neoadjuvant chemohormonal therapy (NCHT) before radical prostatectomy (RP). METHODS: Our NCHT protocol involved complete androgen blockade (CAB) followed by 6 cycles of docetaxel (30 mg/m2) plus estramustine phosphate (560 mg). NCHT was given to 60 patients with PCa before RP, and we compared the clinical and pathological outcomes with those of 349 patients with high-risk PCa who underwent RP alone, using propensity score matching (PSM). The data for those who underwent RP alone were obtained from the Michinoku Japan Urological Cancer Study Group database. RESULTS: In the NCHT group, 10.0% achieved pathological complete response, 3.3% had positive surgical margins, and 13.3% developed severe complications (Clavien–Dindo grade ≥III) after RP. The median follow-up duration was 42.5 months and the 5-year biochemical recurrence (BCR)-free survival was 60.1%. In multivariate analysis, pN+ was an independent prognostic factor for BCR (hazard ratio = 5.25, 1.30–21.20; P = 0.020). In PSM, the BCR rate in the NCHT group was significantly lower than that in the RP alone group (P = 0.021). In subgroup analyses, the BCR rate in patients with a single high-risk factor was significantly lower in the NCHT group than in the RP alone group (P = 0.027). CONCLUSIONS: NCHT before RP can reduce the risk of BCR in patients with high-risk PCa, particularly if a single high-risk factor is present. However, the potential for perioperative complications should be considered. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1133-e1133 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shintaro Narita* More articles by this author Hiromi Sato More articles by this author Mizuki Kobayashi More articles by this author Akane Kikuchi More articles by this author Taketoshi Nara More articles by this author Sohei Kanda More articles by this author Kazuyuki Numakura More articles by this author Atsushi Koizumi More articles by this author Ryuhei Yamamoto More articles by this author Mitsuru Saito More articles by this author Takamitsu Inoue More articles by this author Shigeru Satoh More articles by this author Koji Mitsuzuka More articles by this author Norihiko Tsuchiya More articles by this author Chikara Ohyama More articles by this author Yoichi Arai More articles by this author Hiroshi Nanjo More articles by this author Tomonori Habuchi More articles by this author Expand All Advertisement PDF downloadLoading ...