MP73-11 MEDIUM TERM OUTCOMES FOLLOWING PRIMARY FOCAL CRYOTHERAPY FOR LOCALISED PROSTATE CANCER IN 323 PATIENTS, A MULTI-INSTITUTIONAL OBSERVATIONAL STUDY OVER 10 YEARS

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP73-11 MEDIUM TERM OUTCOMES FOLLOWING PRIMARY FOCAL CRYOTHERAPY FOR LOCALISED PROSTATE CANCER IN 323 PATIENTS, A MULTI-INSTITUTIONAL OBSERVATIONAL STUDY OVER 10 YEARS Deepika Reddy, Max Peters, Marieke Van Son, Mariana Bertoncelli Tanaka, Philipp Huber, Derek Lomas, Arnas Rakauskas, Saiful Miah, David Eldred-Evans, Emma Cullen, Tim Dudderidge, Stuart McCracken, Damian Greene, Raj Nigam, Neil McCartan, Massimo Valerio, Clement Orczyk, Jaspal Virdi, Manit Arya, Taimur Shah, and Hashim Ahmed Deepika ReddyDeepika Reddy More articles by this author , Max PetersMax Peters More articles by this author , Marieke Van SonMarieke Van Son More articles by this author , Mariana Bertoncelli TanakaMariana Bertoncelli Tanaka More articles by this author , Philipp HuberPhilipp Huber More articles by this author , Derek LomasDerek Lomas More articles by this author , Arnas RakauskasArnas Rakauskas More articles by this author , Saiful MiahSaiful Miah More articles by this author , David Eldred-EvansDavid Eldred-Evans More articles by this author , Emma CullenEmma Cullen More articles by this author , Tim DudderidgeTim Dudderidge More articles by this author , Stuart McCrackenStuart McCracken More articles by this author , Damian GreeneDamian Greene More articles by this author , Raj NigamRaj Nigam More articles by this author , Neil McCartanNeil McCartan More articles by this author , Massimo ValerioMassimo Valerio More articles by this author , Clement OrczykClement Orczyk More articles by this author , Jaspal VirdiJaspal Virdi More articles by this author , Manit AryaManit Arya More articles by this author , Taimur ShahTaimur Shah More articles by this author , and Hashim AhmedHashim Ahmed More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003341.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Early outcomes following focal cryotherapy have demonstrated oncological and clinical safety. We report on the largest observational series from 7 centres across the UK. METHODS: 323 patients treated between June 2004- August 2021 with at least 12 months follow up recorded into the International Cryotherapy Evaluation registry were evaluated for safety and oncological outcomes. Kaplan Meier estimates were used to determine the Failure Free Survival (FFS), defined as avoidance of third ablative therapy, salvage whole gland or systemic therapy, prostate cancer metastases or prostate cancer specific death. Adverse events (AE) were reported according to the Clavien-Dindo classification. RESULTS: Median (IQR) follow up was 35 (20-52) months, median patient age was 68 (63-73) years. 174 (54%) patients and 144 (45%) had D’Amico intermediate, and high-risk disease respectively. Neoadjuvant ADT was prescribed in 33 (10%) of cases, quadrant ablation performed in 113 (35%), hemiablation in 194 (60%) and hockey-stick ablation in 16 (5%). FFS at 6.5 years was 71% (95% CI 59-80%); D’Amico intermediate 66% (95%CI 44-81%) and high risk 73% (59-84%), p=0.80 (Figure 1 & 2). 25 (8%) reported an AE with 5 UTIs, 1 epididymo-orchitis, 1 prostatic abscess (conservatively managed) and 1 sepsis event resulting in the only Clavien-Dindo 3 event. There were no rectal injuries. CONCLUSIONS: To our knowledge, this largest study reporting outcomes following primary focal cryotherapy, demonstrates good medium-term oncological outcomes with 99% having intermediate and high risk cancer. There were low rates of adverse events. Our data supports focal therapy as part of the counselling of options for treatment of localised clinically significant prostate cancer. Source of Funding: n/a © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1039 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Deepika Reddy More articles by this author Max Peters More articles by this author Marieke Van Son More articles by this author Mariana Bertoncelli Tanaka More articles by this author Philipp Huber More articles by this author Derek Lomas More articles by this author Arnas Rakauskas More articles by this author Saiful Miah More articles by this author David Eldred-Evans More articles by this author Emma Cullen More articles by this author Tim Dudderidge More articles by this author Stuart McCracken More articles by this author Damian Greene More articles by this author Raj Nigam More articles by this author Neil McCartan More articles by this author Massimo Valerio More articles by this author Clement Orczyk More articles by this author Jaspal Virdi More articles by this author Manit Arya More articles by this author Taimur Shah More articles by this author Hashim Ahmed More articles by this author Expand All Advertisement PDF downloadLoading ...