MP72-19 THE IMPACT OF HEALTH RELATED QUALITY OF LIFE ON CYSTECTOMY PATIENTS USING THE MEDICAL HEALTH OUTCOMES STUDY

Abstract

You have accessJournal of UrologyBladder Cancer: Invasive V1 Apr 2015MP72-19 THE IMPACT OF HEALTH RELATED QUALITY OF LIFE ON CYSTECTOMY PATIENTS USING THE MEDICAL HEALTH OUTCOMES STUDY Brian Winters, George Schade, Sarah Holt, John Gore, Atreya Dash, Michael Porter, and Jonathan Wright Brian WintersBrian Winters More articles by this author , George SchadeGeorge Schade More articles by this author , Sarah HoltSarah Holt More articles by this author , John GoreJohn Gore More articles by this author , Atreya DashAtreya Dash More articles by this author , Michael PorterMichael Porter More articles by this author , and Jonathan WrightJonathan Wright More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2653AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The overall impact on health related quality life (HRQoL) for patients undergoing radical cystectomy (RC) for bladder cancer (BC) is not well quantified on a population-based level. We evaluated post-RC HRQoL in patients with BC undergoing RC compared with non-cancer controls using the SEER-Medical Health Outcomes Survey (MHOS) database. METHODS The SEER-MHOS database (1998-2011) was used to identify patients with a BC diagnosis and MHOS survey data. Each included patient was surveyed at intervals with the SF-36 or its short-form, the VR-12, from which the mental component summary (MCS) and physical component summary (PCS) scores were derived. 129 patients undergoing RC were identified with available MHOS results within 5 years of surgery. RC patients were propensity score matched 1:5 to non-cancer controls (n=645) on age, gender, race, marital status, education, smoking status and comorbidities (HTN, angina, CHF, MI, stoke, COPD, DM, sciatica, arthritis). Differences in MCS and PCS scores as well as self-reported activities of daily living (ADLs) between RC patients and non-cancer controls were evaluated with linear regression analysis and the Fisher's exact test where appropriate. RESULTS Overall, mean MCS (48.9 and 50.8, p = 0.01) and PCS (35.0 and 39.7, p < 0.001) scores were significantly lower for cases than matched controls, respectively. When stratified by length of time from RC (<6 mos, 6-12 mos, 12-18 mos, 18-24 mos, 24-60 mos), adjusted MCS scores were not significantly different between groups, with the exception of a decrease in MCS in post-RC patients in the 24-60 month group (p=0.04). PCS scores were significantly lower among RC patients at all time points except 18-24 months after RC. Evaluation of patient-reported ADLs revealed worse physical functioning among RC patients compared with controls including greater difficulty or inability to perform: bathing (24% vs. 13%, p=0.002), dressing (21% vs. 12%, p=0.009), eating (11% vs. 6%, p=0.047), and using the toilet (16% vs. 9%, p=0.02). There were no significant differences between groups with respect to walking or getting in/out of a chair. Overall, post RC patients rated their general health (p=0.0003) and health relative to peers of same age (p = 0.02) as significantly decreased compared to controls. CONCLUSIONS Patients undergoing RC for BC have worse physical HRQoL and greater difficulty performing ADLs compared with non-cancer controls. Further longitudinal study is needed to better quantify HRQoL in patients undergoing cystectomy for bladder cancer. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e928 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Brian Winters More articles by this author George Schade More articles by this author Sarah Holt More articles by this author John Gore More articles by this author Atreya Dash More articles by this author Michael Porter More articles by this author Jonathan Wright More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...