MP72-02 DO THE METABOLIC SYNDROME AND CHRONIC HISTOLOGICAL CHANGES EFFECT ON RESIDUAL KIDNEY FUNCTION IN LIVING KIDNEY DONORS?

Abstract

You have accessJournal of UrologyTransplantation & Vascular Surgery II1 Apr 2014MP72-02 DO THE METABOLIC SYNDROME AND CHRONIC HISTOLOGICAL CHANGES EFFECT ON RESIDUAL KIDNEY FUNCTION IN LIVING KIDNEY DONORS? Kyung Hwa Choi, Kwang Hyun Kim, Young Eun Yoon, Kwang-suk Lee, Seung Choul Yang, Kyu Ha Huh, Dong Jin Joo, Myoung Soo Kim, Soon Il Kim, Yu Seun Kim, and Woong Kyu Han Kyung Hwa ChoiKyung Hwa Choi More articles by this author , Kwang Hyun KimKwang Hyun Kim More articles by this author , Young Eun YoonYoung Eun Yoon More articles by this author , Kwang-suk LeeKwang-suk Lee More articles by this author , Seung Choul YangSeung Choul Yang More articles by this author , Kyu Ha HuhKyu Ha Huh More articles by this author , Dong Jin JooDong Jin Joo More articles by this author , Myoung Soo KimMyoung Soo Kim More articles by this author , Soon Il KimSoon Il Kim More articles by this author , Yu Seun KimYu Seun Kim More articles by this author , and Woong Kyu HanWoong Kyu Han More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2241AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Metabolic syndrome (MS) has been increasing over the last decade, and its relationship with renal function and histological abnormality has been an important clinical issue. We studied association of MS and histological findings with renal function in living kidney donors METHODS Implantation biopsy of 162 cases of living kidney transplantation between 2010 and 2011 were followed. NCEP ATPIII and ¡¯07 Banff criteria were used to define MS and histological characteristics. Chronic histological change(CHC) were characterized by following: any glomerulosclerosis, any interstitial fibrosis or any arteriosclerosis. Perioperative estimated GFR (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula and urine microalbumin/creatinin ratio was calculated. Univariate and multivariate regression analyses were performed to identify the factors related to CHC and postoperative 6 month chronic kidney disease (MDRD GFR< 60ml/min/1.73m2). RESULTS The mean ages of MS group and non-MS group were 48.4 and 38.6 years respectively. The mean preoperative MDRD GFRs of each group were 85.7 vs 93.7 ml/min/1.73m2 (p=0.031). The MDRD GFR before postoperative 1 month was lower in MS group than non-MS group (50.7 vs 61.8, p<0.001). Donors with MS were more likely to have a CHC (Figure 1, p=0.004). The mean preoperative MDRD GFR of CHC and normal group were 88.9 vs 95.0 (p=0.028). The MDRD GFR before postoperative 1 month and postoperative 6 month were lower in CHC group than normal group (52.5 vs 62.4, p=0.003 and 61.2 vs 66.7, p=0.026, respectively). Older donor and presence of MS were related to CHC (Table 1). And older donor, lower preoperative MDRD GFR and presence of CHC were the positive related factors for postoperative 6 month chronic kidney disease (Table 2). However, presence of MS was not related factor. CONCLUSIONS Our study revealed that MS is related with CHC in implantation biopsy and CHC is associated with postoperative 6 month chronic kidney disease in living kidney donors. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e823 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Kyung Hwa Choi More articles by this author Kwang Hyun Kim More articles by this author Young Eun Yoon More articles by this author Kwang-suk Lee More articles by this author Seung Choul Yang More articles by this author Kyu Ha Huh More articles by this author Dong Jin Joo More articles by this author Myoung Soo Kim More articles by this author Soon Il Kim More articles by this author Yu Seun Kim More articles by this author Woong Kyu Han More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...