MP71-17 LOWER URINARY TRACT SYMPTOMS AND RISK OF INCIDENT NON-SPINE FRACTURE AMONG OLDER US MEN

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Evaluation and Symptoms1 Apr 2015MP71-17 LOWER URINARY TRACT SYMPTOMS AND RISK OF INCIDENT NON-SPINE FRACTURE AMONG OLDER US MEN Lynn Marshall, Jodi Lapidus, Jack Wiedrick, Kathleen Holton, Elizabeth Barrett Connor, and J. Kellogg Parsons Lynn MarshallLynn Marshall More articles by this author , Jodi LapidusJodi Lapidus More articles by this author , Jack WiedrickJack Wiedrick More articles by this author , Kathleen HoltonKathleen Holton More articles by this author , Elizabeth Barrett ConnorElizabeth Barrett Connor More articles by this author , and J. Kellogg ParsonsJ. Kellogg Parsons More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2630AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Lower urinary tract symptoms (LUTS) are associated with an increased risk of falls in older men. Falls are a strong risk factor for fractures. Therefore, we assessed associations of LUTS severity with fracture risk in community dwelling U.S. men ages 65 years or older METHODS We conducted a prospective study in the Osteoporotic Fractures in Men (MrOS) cohort. The American Urological Association Symptom Index (AUA-SI), prescription medications for LUTS, hip bone mineral density (BMD), and other traditional fracture risk factors were recorded at baseline (2000-02) and every two years thereafter for a total of three assessments. LUTS severity was categorized from the AUA-SI as mild (0-7 points), moderate (8-19 points), or severe (>19 points). Men were followed from the date of their baseline visit to date of first non-spine fracture, death, voluntary withdrawal, or third study visit (2007-09), whichever occurred first. Associations of LUTS severity with fracture rate were estimated with hazard ratios (HR) and 95% confidence intervals (CI) from extended proportional hazards regression with age as the timescale. Models accounted for competing risks from death. RESULTS Among 5,989 men with baseline AUA-SI score and hip BMD measures, 576 incident non-spine fractures occurred during 35,947 person-years of follow-up. Crude fracture rates per 1000 person-years in each LUTS severity category did not differ statistically among men who used prescription LUTS medications and non-users (Figure 1). Adjusted for age and compared to mild LUTS, HR (95% CI) were 1.0 (0.9, 1.2) for moderate LUTS and 1.3 (1.0, 1.7) for severe LUTS, respectively. Further adjustment for hip BMD, falls in the past year, and prevalent fracture before baseline attenuated the HR to 0.9 (0.8, 1.1) for moderate and 1.1 (0.8, 1.4) for severe LUTS. CONCLUSIONS In this cohort of older US men, the association of severe LUTS with higher rate of incident non-spine fracture was explained by traditional fracture risk factors. Older men with LUTS may benefit from screening and counseling about their fracture risk factors. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e918-e919 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Lynn Marshall More articles by this author Jodi Lapidus More articles by this author Jack Wiedrick More articles by this author Kathleen Holton More articles by this author Elizabeth Barrett Connor More articles by this author J. Kellogg Parsons More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...