MP70-08 FOCAL THERAPY FOR PROSTATE CANCER: DO APICAL LESIONS CORRELATE WITH WORSE OUTCOMES?

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy II (MP70)1 Apr 2020MP70-08 FOCAL THERAPY FOR PROSTATE CANCER: DO APICAL LESIONS CORRELATE WITH WORSE OUTCOMES? Armando Stabile*, Nicola Fossati, Giorgio Gandaglia, Marco Moschini, Petr Macek, Natalie Cathala, Xavier Cathelineau, Simone Scuderi, Daniele Robesti, Elio Mazzone, Giuseppe Rosiello, Marco Bandini, Carlo Bravi, Nazareno Suardi, Pierre I Karakiewicz, Alberto Briganti, Francesco Montorsi, and Rafael Sanchez-Salas Armando Stabile*Armando Stabile* More articles by this author , Nicola FossatiNicola Fossati More articles by this author , Giorgio GandagliaGiorgio Gandaglia More articles by this author , Marco MoschiniMarco Moschini More articles by this author , Petr MacekPetr Macek More articles by this author , Natalie CathalaNatalie Cathala More articles by this author , Xavier CathelineauXavier Cathelineau More articles by this author , Simone ScuderiSimone Scuderi More articles by this author , Daniele RobestiDaniele Robesti More articles by this author , Elio MazzoneElio Mazzone More articles by this author , Giuseppe RosielloGiuseppe Rosiello More articles by this author , Marco BandiniMarco Bandini More articles by this author , Carlo BraviCarlo Bravi More articles by this author , Nazareno SuardiNazareno Suardi More articles by this author , Pierre I KarakiewiczPierre I Karakiewicz More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Rafael Sanchez-SalasRafael Sanchez-Salas More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000950.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: In the context of focal therapy (FT) the presence of an apical lesion (AL) is typically considered a more challenging scenario characterised by a higher risk of treatment failure. METHODS: We identified 274 men receiving FT for prostate cancer (PCa) using either HIFU or cryotherapy at a high volume centre between 2009 to 2018. The primary outcome was to explore the relationship between AL and the rate of any additional treatment and radical treatment after FT. The secondary outcome was to assess whether AL was related with post-operative urinary retention (UR). Multivariable Cox regression analyses were used to address both the outcomes. Covariates for primary outcome were PSA, clinical stage (T1 vs T2), prostate volume, maximum cancer core length, percentage of positive cores and type of energy (HIFU vs Cryo), whereas for secondary outcome were type of energy and prostate volume. RESULTS: 166 and 108 men received FT with HIFU and Cryo. Overall, 39% (106) and 31% (85) received at least an additional treatment and a radical treatment after FT, respectively, with a median follow-up of 51 months (IQR: 70-29). 9% (24) men experienced post-operative UR. At Cox regression presence of an AL was not significantly associated with higher risk of both any additional treatment and radical treatment (all p>0.4), whereas PSA resulted the only independent predictor of the outcomes tested (OR: 0.12; p=0.005). AL was neither significantly associated with a higher risk of post-operative UR (p=0.66). CONCLUSIONS: The presence of an AL was associated neither with a worse oncological outcome nor with higher rate of post-operative UR. According to this single institution experience, presence of AL should not be considered an exclusion criteria for FT. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1058-e1058 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Armando Stabile* More articles by this author Nicola Fossati More articles by this author Giorgio Gandaglia More articles by this author Marco Moschini More articles by this author Petr Macek More articles by this author Natalie Cathala More articles by this author Xavier Cathelineau More articles by this author Simone Scuderi More articles by this author Daniele Robesti More articles by this author Elio Mazzone More articles by this author Giuseppe Rosiello More articles by this author Marco Bandini More articles by this author Carlo Bravi More articles by this author Nazareno Suardi More articles by this author Pierre I Karakiewicz More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Rafael Sanchez-Salas More articles by this author Expand All Advertisement PDF downloadLoading ...