MP7-03 IMAGING MICROSTRUCTURAL PROPERTIES OF THE KIDNEYS USING DIFFUSION TENSOR- MRI

Abstract

You have accessJournal of UrologyImaging/Radiology II1 Apr 2014MP7-03 IMAGING MICROSTRUCTURAL PROPERTIES OF THE KIDNEYS USING DIFFUSION TENSOR- MRI Sophie van Baalen, Martijn Froeling, Alexander Leemans, Bennie ten Haken, Aart Klijn, Tom de Jong, and Pieter Dik Sophie van BaalenSophie van Baalen More articles by this author , Martijn FroelingMartijn Froeling More articles by this author , Alexander LeemansAlexander Leemans More articles by this author , Bennie ten HakenBennie ten Haken More articles by this author , Aart KlijnAart Klijn More articles by this author , Tom de JongTom de Jong More articles by this author , and Pieter DikPieter Dik More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.326AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Acute Pyelonephritis (APN) is a common disease in children: about 2.7% of girls and 1% of boys have an APN by the age of 7. APN can result in irreversible damage to the renal parenchyma, affecting the growth and development of the kidney and possibly leading to renal insufficiency, protein loss and hypertension. All children receive a DMSA scintigraphy 6 months after an APN episode to assess the occurrence and extent of renal scars. The radiation dose of 1 mSv/examination imposes a long-term risk in young children. Replacing the DMSA scan with an MRI scan for children with APN would eliminate the risks associated with using ionizing radiation. A promising MRI technique is Diffusion Tensor Imaging (DTI). DTI enables measuring the direction and extend of water diffusion in renal tissue, without using contrast agents. In this study, MRI-DTI was used for kidney imaging to evaluate whether this technology can visualize the microstructural architecture of healthy kidney tissues. METHODS Ten healthy volunteers were scanned on a 3 Tesla MRI scanner. The resulting images were processed to enable Diffusion-Tensor based tractography, visualizing the 3D tissue structure of the kidney. The diffusion parameters Fractional Anisotropy (FA) and Mean Diffusivity (MD) were measured by drawing regions of interest in the medulla and cortex. This study was approved by the ethical committee of our institution. RESULTS The radial orientation of the medullar tissue was visualized and the pyelum contour was segmented. Tracts originate in the cortex and convolute in multiple papillae, at the edge of the pyelum contour, reflecting the microstructure of medulla, consisting of radially oriented straight tubules and vascular network. Differentiation of cortical and medullary tissue based on FA and MD measurement was possible. One volunteer happened to have a dysplastic kidney with evident disturbed microstructural properties on the MRI-DTI tractography image. CONCLUSIONS MRI-DTI is able to visualize the microstructural architecture, especially the renal pyramids, the papillae and major and minor calyxes of the kidney. We are sure that in near future we will be able to visualize alterations in the microstructure e.g. scar tissue formation using this method. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e65-e66 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Sophie van Baalen More articles by this author Martijn Froeling More articles by this author Alexander Leemans More articles by this author Bennie ten Haken More articles by this author Aart Klijn More articles by this author Tom de Jong More articles by this author Pieter Dik More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...