MP67-13 RELATIONSHIP BETWEEN FRAILTY AND MENTAL HEALTH AND QUALITY OF LIFE IN LONG-TERM PROSTATE CANCER SURVIVORS AFTER RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP67-13 RELATIONSHIP BETWEEN FRAILTY AND MENTAL HEALTH AND QUALITY OF LIFE IN LONG-TERM PROSTATE CANCER SURVIVORS AFTER RADICAL PROSTATECTOMY Kathleen Herkommer, Valentin Meissner, Lukas Lunger, Kolja Imhof, Matthias Jahnen, Donna Ankerst, Andreas Dinkel, Stefan Schiele, and Juergen Gschwend Kathleen HerkommerKathleen Herkommer More articles by this author , Valentin MeissnerValentin Meissner More articles by this author , Lukas LungerLukas Lunger More articles by this author , Kolja ImhofKolja Imhof More articles by this author , Matthias JahnenMatthias Jahnen More articles by this author , Donna AnkerstDonna Ankerst More articles by this author , Andreas DinkelAndreas Dinkel More articles by this author , Stefan SchieleStefan Schiele More articles by this author , and Juergen GschwendJuergen Gschwend More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003330.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Aging-related deficits that eventually manifest as frailty are emerging as an important determinant for mental health and quality of life in older patients with cancer. The objective of the current study was (I) to assess the prevalence of frailty and (II) to elucidate the relationship between frailty and mental health as well as quality of life in long-term prostate cancer survivors after radical prostatectomy. METHODS: 2979 prostate cancer survivors from the multicenter German Familial Prostate Cancer Database were included. Patients completed standardized patient-reported outcome measures on the outcomes of interest frailty (Groningen Frailty indicator), quality of life (EORTC QLQ-C30), and anxiety/depressive symptoms (PHQ-4). Additionally, sociodemographic and clinicopathological factors as well as cancer-related self-perception were assessed. Chi square tests were used to detect differences of selected variables in frail and non-frail patients. RESULTS: The patients’ mean age was 79 years (SD=6.4) and mean time since radical prostatectomy was 18 years (SD=3.7). 33% (985/2979) of the patients were classified as frail. Regarding mental health and quality of life, frail patients reported more often depressive (24% vs. 4.0%; p<0.01) and anxiety (21% vs. 2.0%; p<0.01) symptoms and lower quality of life (mean quality of life score of 50 out of 100 vs. 70 out of 100; p<0.01) compared to non-frail patients. Frail patients were older (81 vs. 79 years; p<0.01), less often partnered (80% vs. 90%; p<0.01), and less often satisfied with their economic situation 96% vs. 99%; p<0.01) compared to non-frail patients. Frail patients had more often a secondary cancer (16% vs 12%; p<0.01), biochemical recurrence since radical prostatectomy (41% vs. 34%; p<0.01), and were more often under current prostate cancer therapy (15% vs. 8.0%; p<0.01). Cancer-related self-perception showed significant differences between frail and non-frail patients (p<0.01). For instance, frail patients perceived themselves more often as “victim” (3.0% vs. 1.4%), whereas non-frail patients favored the term “cancer conqueror” (10% vs. 7.4%). CONCLUSIONS: Prevalence of frailty is high in elderly long-term prostate cancer survivors. The association with poorer mental health and lower quality of life indicates the need for an integrated care approach including further geriatric assessment and possible interventions to improve health outcomes of these patients. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e948 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kathleen Herkommer More articles by this author Valentin Meissner More articles by this author Lukas Lunger More articles by this author Kolja Imhof More articles by this author Matthias Jahnen More articles by this author Donna Ankerst More articles by this author Andreas Dinkel More articles by this author Stefan Schiele More articles by this author Juergen Gschwend More articles by this author Expand All Advertisement PDF downloadLoading ...