MP67-05 LAROSCOPIC RADICAL PROSTATECTOMY USING A REAL-TIME LYMPHANGIOGRAPHY WITH TRANSPERINEAL INJECTION OF INDOCYANINE GREEN: RESULTS FROM A PROSPECTIVE STUDY

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy III (MP67)1 Apr 2020MP67-05 LAROSCOPIC RADICAL PROSTATECTOMY USING A REAL-TIME LYMPHANGIOGRAPHY WITH TRANSPERINEAL INJECTION OF INDOCYANINE GREEN: RESULTS FROM A PROSPECTIVE STUDY Francesco Claps*, Miguel Ramirez-Backhaus, Alvaro Gomez-Ferrer, Maria Carmen Mir Maresma, Juan Casanova Ramón-Borja, Argimiro Collado Serra, Jose Luis Dominguez-Escrig, Juan Manuel Mascaros, Ana Calatrava Fons, Carlo Trombetta, and Jose Rubio Briones Francesco Claps*Francesco Claps* More articles by this author , Miguel Ramirez-BackhausMiguel Ramirez-Backhaus More articles by this author , Alvaro Gomez-FerrerAlvaro Gomez-Ferrer More articles by this author , Maria Carmen Mir MaresmaMaria Carmen Mir Maresma More articles by this author , Juan Casanova Ramón-BorjaJuan Casanova Ramón-Borja More articles by this author , Argimiro Collado SerraArgimiro Collado Serra More articles by this author , Jose Luis Dominguez-EscrigJose Luis Dominguez-Escrig More articles by this author , Juan Manuel MascarosJuan Manuel Mascaros More articles by this author , Ana Calatrava FonsAna Calatrava Fons More articles by this author , Carlo TrombettaCarlo Trombetta More articles by this author , and Jose Rubio BrionesJose Rubio Briones More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000947.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Current standard imaging procedures have limited ability to predict lymph node (LN) involvement in clinically localized prostate cancer (PCa) and extended pelvic lymph node dissection (ePLND) during radical prostatectomy (RP) remains the most accurate staging procedure. However, meticulous ePLND is time-consuming and associated with an increased risk of morbidity. In order to improve these aspects, sentinel LN mapping with different guided techniques has been proposed over the years. The primary aim of this study is to evaluate the effectiveness of indocyanine green (ICG)-guided ePLND to assess regional LN status in patients who underwent RP. Secondary objective is to evaluate the potential role of a selective ICG lymph node dissection (LND) in patients with ≤ 2 LN metastasis which according to the literature are those who may more benefit from ePLND. METHODS: Data about 226 consecutive patients underwent laparoscopic RP with ICG-guided ePLND at our Department were prospectively evaluated. A solution of 25 mg ICG in 5 ml sterile water was transperineally injected. PLND started with the ICG stained nodes followed by extended template. Primary outcome measures were sensitivity (S), negative predictive value (NPV) and likelihood ratio of a negative test (LRn) of ICG-guided procedure. To our knowledge this study shows data about the largest cohort of patients underwent ICG-guided ePLND. RESULTS: Overall, median age of patients was 64.8 years with a median PSA of 6.6 ng/ml. Extracapsular disease occurred in 50.9% of patients, Gleason score ≥ 8 was reported in 11.9% cases and positive surgical margins rate was 24.3%. Median number of nodes retrieved was 22 (IQR 16-27) and median number of ICG stained per patient nodes was 6 (IQR 4-9). Overall 4939 nodes were removed and 1599 (32.4%) were fluorescent in vivo. Node-positive disease was found in 58 (25.7%), of which 53 (91.4%) had some of the metastatic LNs stained by ICG, while 5 (8.6%) were false negative. Therefore 97.8% of the sample was properly classified by ICG-guided ePNLD (S: 91.4%, NPV: 97.1% and LRn: 8.6%). Considering 209 (92.5%) patients with 0, 1 or 2 metastatic LNs, 39 (18.7%) had a node-positive disease of which 34 (87.2%) had metastatic ICG stained LNs. Again, 97.6% were properly classified by ICG approach (S: 87.2%, NPV: 97.1% and LRn: 12.8%). These 39 node-positive patients had a total of 48 metastatic LNs and all except 9 (18.8%) were fluorescent in vivo (S: 81.2%). CONCLUSIONS: ICG guidance correctly stage 97% of cases. Furthermore, its high NPV will allow to avoid ePLND as soon as an accurate intraoperative analysis is available. Among those patients in whom the LND may have a potentially curative role, ICG alone would have lost only 9 metastatic LNs. This suggest that maybe there is a place for selective LND in patients with limited LN metastatic burden. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1027-e1027 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Francesco Claps* More articles by this author Miguel Ramirez-Backhaus More articles by this author Alvaro Gomez-Ferrer More articles by this author Maria Carmen Mir Maresma More articles by this author Juan Casanova Ramón-Borja More articles by this author Argimiro Collado Serra More articles by this author Jose Luis Dominguez-Escrig More articles by this author Juan Manuel Mascaros More articles by this author Ana Calatrava Fons More articles by this author Carlo Trombetta More articles by this author Jose Rubio Briones More articles by this author Expand All Advertisement PDF downloadLoading ...