MP67-13 GLOBAL TRENDS IN INCIDENCE AND BURDEN OF UROLITHIASIS FROM 1990-2019: AN ANALYSIS OF GLOBAL BURDEN OF DISEASE STUDY DATA

Abstract

You have accessJournal of UrologyGlobal Health/Humanitarian (MP67)1 Sep 2021MP67-13 GLOBAL TRENDS IN INCIDENCE AND BURDEN OF UROLITHIASIS FROM 1990-2019: AN ANALYSIS OF GLOBAL BURDEN OF DISEASE STUDY DATA Jacob Lang, Aparna Narendrula, Ahmed El-Zawahry, Puneet Sindhwani, and Obi Ekwenna Jacob LangJacob Lang More articles by this author , Aparna NarendrulaAparna Narendrula More articles by this author , Ahmed El-ZawahryAhmed El-Zawahry More articles by this author , Puneet SindhwaniPuneet Sindhwani More articles by this author , and Obi EkwennaObi Ekwenna More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002028.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urolithiasis is among the most common urologic diagnoses globally, with substantial burden and cost on healthcare systems worldwide. Increasing evidence links urolithiasis with an array of risk factors, including diet and lifestyle trends, non-communicable diseases such as diabetes and obesity, and global warming. Our study examines geographic, temporal, and sociodemographic patterns in global disease burden and incidence of urolithiasis using Global Burden of Disease (GBD) study data from 1990-2019. METHODS: We extracted data on age standardized incidence rate (ASIR), prevalence, and disability adjusted life years (DALYs) attributed to urolithiasis for 21 regions, including 195 countries, from 1990-2019 from the GBD Study. Data was analyzed at the global and regional levels, as well as stratified by Socio-Demographic Index (SDI) to assess geographic and socioeconomic trends. Analysis was performed using Stata and Tableau Software. RESULTS: Globally, the ASIR of urolithiasis decreased from 1696.2 (95% CI 1,358.1-2,078.1) cases per 100,000 population in 1990 to 1,394.0 (95% CI 1,126.4-1,688.2) cases per 100,000 population in 2019. When analyzed by SDI quintile (Figure 1), High-Middle SDI countries demonstrated the highest ASIR across all study years, while Low SDI countries demonstrated the lowest ASIR of urolithiasis, increasing slightly over the study period. When analyzed by GBD region, Eastern Europe demonstrated consistently higher ASIR of urolithiasis than all other regions, not falling below 4,198.8 (95% CI 3,403.8-5,078.8.) cases per 100,000 population at any point during the study period. The total DALYs attributed to urolithiasis increased over the study period, while there was an overall decreasing trend in the rate of DALYs per 100,000 population. These trends were consistent across low, low-middle and middle SDI groups. CONCLUSIONS: Disability-adjusted life years attributed to urolithiasis have increased globally since 1990, while the ASIR and DALY’s per 100,000 population have decreased in most SDI groups. Of note, both the total DALYs and ASIR in the lowest SDI group have increased since 1990. With the substantial burden of disease attributed to urolithiasis, global and national strategies to address urolithiasis prevention and treatment are necessary. Source of Funding: N/A © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e514-e514 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jacob Lang More articles by this author Aparna Narendrula More articles by this author Ahmed El-Zawahry More articles by this author Puneet Sindhwani More articles by this author Obi Ekwenna More articles by this author Expand All Advertisement Loading ...