MP67-13 DOES HISTOSCANNING (™) PREDICT POSITIVE RESULTS IN PROSTATE BIOPSY? A RETROSPECTIVE ANALYSIS OF 1,188 SEXTANTS OF THE PROSTATE

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening IV1 Apr 2014MP67-13 DOES HISTOSCANNING (™) PREDICT POSITIVE RESULTS IN PROSTATE BIOPSY? A RETROSPECTIVE ANALYSIS OF 1,188 SEXTANTS OF THE PROSTATE Jonas Schiffmann, Johannes Fischer, Pierre Tennstedt, Burkhardt Beyer, Katharina Böhm, Uwe Michl, Markus Graefen, and Georg Salomon Jonas SchiffmannJonas Schiffmann More articles by this author , Johannes FischerJohannes Fischer More articles by this author , Pierre TennstedtPierre Tennstedt More articles by this author , Burkhardt BeyerBurkhardt Beyer More articles by this author , Katharina BöhmKatharina Böhm More articles by this author , Uwe MichlUwe Michl More articles by this author , Markus GraefenMarkus Graefen More articles by this author , and Georg SalomonGeorg Salomon More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2080AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES HistoScanning (™) (HS) is an ultrasound-based tissue characterization technique with encouraging results in the detection of prostate cancer (PCA). To evaluate the prediction of positive biopsy findings by HS in the largest patient cohort so far we retrospectively analyzed biopsy and HS results. METHODS Patients with prostate biopsy who received HS were included. A single examiner re-analyzed all HS data in accordance to sextants of the prostate. For each sextant the corresponding results were compared. The area under the receiver operating characteristic curve (AUC) for the prediction of positive biopsy by HS was calculated. According to tumor volume measured by HS (TVHS) > 0, > 0.2 and > 0.5ml the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were analyzed. RESULTS Overall, 198 men were identified and 1,188 sextants were analyzed. The AUC to predict positive biopsy results by HS was 0.58. According to TVHS (> 0, > 0.2 and > 0.5ml) the sensitivity and specificity for predicting positive biopsy results by HS were 83.7% and 25.2%, 57.5% and 55.0% and 35.0% and 76.6%, respectively. CONCLUSIONS Positive HS signals do not predict positive prostate biopsy results according to sextant analysis. We do not recommend a variation of well-established random biopsy patterns or a reduction of the number of biopsy cores in accordance to HS findings at the moment. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e754 Peer Review Report Advertisement Copyright & Permissions© 2014MetricsAuthor Information Jonas Schiffmann More articles by this author Johannes Fischer More articles by this author Pierre Tennstedt More articles by this author Burkhardt Beyer More articles by this author Katharina Böhm More articles by this author Uwe Michl More articles by this author Markus Graefen More articles by this author Georg Salomon More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...