MP67-13 COMPARISON OF MORBIDITY BETWEEN LIMITED AND EXTENDED PELVIC LYMPH NODE DISSECTION FOR PROSTATE CANCER: RESULTS FROM A LARGE, CLINICALLY-INTEGRATED, RANDOMIZED TRIAL

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy III (MP67)1 Apr 2020MP67-13 COMPARISON OF MORBIDITY BETWEEN LIMITED AND EXTENDED PELVIC LYMPH NODE DISSECTION FOR PROSTATE CANCER: RESULTS FROM A LARGE, CLINICALLY-INTEGRATED, RANDOMIZED TRIAL Karim Touijer, Daniel D. Sjoberg, Nicole Benfante, Claudia Mercader Barrull*, Natalia Picola Brau, Inés Rivero Belenchón, Vincent Laudone, Behfar Ehdaie, James A. Eastham, Peter T. Scardino, and Andrew Vickers Karim TouijerKarim Touijer More articles by this author , Daniel D. SjobergDaniel D. Sjoberg More articles by this author , Nicole BenfanteNicole Benfante More articles by this author , Claudia Mercader Barrull*Claudia Mercader Barrull* More articles by this author , Natalia Picola BrauNatalia Picola Brau More articles by this author , Inés Rivero BelenchónInés Rivero Belenchón More articles by this author , Vincent LaudoneVincent Laudone More articles by this author , Behfar EhdaieBehfar Ehdaie More articles by this author , James A. EasthamJames A. Eastham More articles by this author , Peter T. ScardinoPeter T. Scardino More articles by this author , and Andrew VickersAndrew Vickers More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000947.013AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Pelvic lymph node dissection (PLND) in prostate cancer is controversial. Although it represents the most reliable procedure for lymph node staging, the extended PLND was reported to be associated with increased morbidity. METHODS: Between October 2011 and March 2017, men were consented to the trial and underwent radical prostatectomy at Memorial Sloan Kettering Cancer Center. The study design was a cluster randomization with crossover. Each surgeon was randomized to use a limited (external iliac nodal packet) vs. extended (external iliac, obturator fossa and hypogastric nodal packets) PLND template for a 3-month period. At the end of the 3-month period, surgeons were once again randomized. Morbidity data within 30 days of surgery was prospectively graded and collected in the clinical research database. RESULTS: A total of 1574 patients were randomized: 811 randomized to the extended and 763 to the limited template. Overall the rate of complication was 10.5% in the limited PLND group vs. 8.5% in the extended PLND group. There were no grade IV or V complications. Rates for grade II and III complications were similar (7.2% in limited vs. 6.3% in extended). CONCLUSIONS: In this large randomized trial the overall rate of grade II and III complications was low. There was no significant difference in complication rates between the limited and extended PLND. Source of Funding: None. © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1030-e1030 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Karim Touijer More articles by this author Daniel D. Sjoberg More articles by this author Nicole Benfante More articles by this author Claudia Mercader Barrull* More articles by this author Natalia Picola Brau More articles by this author Inés Rivero Belenchón More articles by this author Vincent Laudone More articles by this author Behfar Ehdaie More articles by this author James A. Eastham More articles by this author Peter T. Scardino More articles by this author Andrew Vickers More articles by this author Expand All Advertisement PDF downloadLoading ...