MP67-09 RISK ASSESSMENT TO PREDICT A POSITIVE BIOPSY USING SHEARWAVE ELASTOGRAPHY.

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening IV1 Apr 2014MP67-09 RISK ASSESSMENT TO PREDICT A POSITIVE BIOPSY USING SHEARWAVE ELASTOGRAPHY. Katharina Boehm, Burkhard Beyer, Jonas Schiffmann, Pierre Tennstedt, Lars Budaeus, and Georg Salomon Katharina BoehmKatharina Boehm More articles by this author , Burkhard BeyerBurkhard Beyer More articles by this author , Jonas SchiffmannJonas Schiffmann More articles by this author , Pierre TennstedtPierre Tennstedt More articles by this author , Lars BudaeusLars Budaeus More articles by this author , and Georg SalomonGeorg Salomon More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2076AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Purpose in prostate cancer detection is the increase of positive biopsies and the decrease of insignificant prostate cancer. Therefore, selecting patients for biopsy should be improved. Shearwave Elastographie (SWE) has been reported to have a better visualization of prostate cancer foci compared to grey scale ultrasound. Aim of this study is to evaluate the possibility to select patients prior to biopsy with SWE. METHODS 106 patients underwent a 12 core prostate biopsy. Before taking the biopsy, every prostate gland was scanned with SWE and classified by the urologist into suspect (80 patients) or not suspect (26 patients). Patients underwent their first or second to 7th biopsy (46 and 50 patients, missing data 10 patients). Univariate analysis including age, prostate volume, PSA-level, clinical stage and SWE finding was performed. RESULTS Overall detection rate for prostate cancer was 46% (49/106). Detection rate could be increased up to 55% (44/80) by using SWE for risk stratification. Patients with a positive biopsy had mostly suspect SWE findings (90%, 44/49) (p=0.0001). Otherwise 10% (5/51) of the patients with no suspect SWE findings harbored prostate cancer, all eligible for active surveillance but for one. Overall detection rate for the first biopsy was 65% (30/46) and for following biopsies 36% (18/50). CONCLUSIONS SWE is useful for patient selection prior to prostate biopsy. Risk of missing significant prostate cancer should be negligible according to our results and harm due to prostate biopsy could be avoided by selecting patients with SWE. Nonetheless specificity of this imaging tool is limited. Tbl.1 Detection rate, sensitivity and specificity in patients with primary or repeated biopsy setting. Risk stratification by the use of SWE. detection rate suspect SWE finding n= 80 (sensitivity) normal SWE finding n= 26 (specificity) p-value overall n= 106 49 (46.2) 44 (89.8) 21 (36.8) 0.0001 1th biopsy n= 46 30 (65.2) 27 (90.0) 8 (50.0) 0.0028 repeated biopsy n=50 18 (36) 16 (88.9) 8 (25.0) 0.2218 © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e752 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Katharina Boehm More articles by this author Burkhard Beyer More articles by this author Jonas Schiffmann More articles by this author Pierre Tennstedt More articles by this author Lars Budaeus More articles by this author Georg Salomon More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...