MP66-08 POLYMORPHISMS OF GENES RELATED TO OESTROGEN METABOLISM AND THE RISK OF PROSTATE CANCER IN TWO POPULATIONS OF AFRICAN DESCENT.

Abstract

You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II1 Apr 2016MP66-08 POLYMORPHISMS OF GENES RELATED TO OESTROGEN METABOLISM AND THE RISK OF PROSTATE CANCER IN TWO POPULATIONS OF AFRICAN DESCENT. Laurent BRUREAU, Dieudonne MONINGO, Elise EMEVILLE, Severine FERDINAND, Marc ROMANA, Pascal BLANCHET, and Luc MULTIGNER Laurent BRUREAULaurent BRUREAU More articles by this author , Dieudonne MONINGODieudonne MONINGO More articles by this author , Elise EMEVILLEElise EMEVILLE More articles by this author , Severine FERDINANDSeverine FERDINAND More articles by this author , Marc ROMANAMarc ROMANA More articles by this author , Pascal BLANCHETPascal BLANCHET More articles by this author , and Luc MULTIGNERLuc MULTIGNER More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1282AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Some polymorphisms of genes coding for enzymes involved in oestrogen metabolism are risk factors for prostate cancer. However, few studies have been conducted on populations of African origin, which are known to have a high risk of prostate cancer. We studied the functional polymorphisms of CYP17, CYP19, CYP1B1, COMT and UGT1A1 and risk of prostate cancer in two different populations of African descent. METHODS In Guadeloupe (French West Indies), we compared 498 patients with prostate cancer and 565 control subjects. In Kinshasa (DRC), 162 patients with prostate cancer were compared with 144 controls. Genetic polymorphisms have been determined by the technique of SNaPshot PCR and for repeat nucleotides. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (CI). RESULTS The AA genotype and allele of rs4680 (COMT) appear to be inversely associated with risk of prostate cancer in models adjusted for African men (OR: 0.26 (95% CI 0.08 to 0.83), p = 0.003) and Afro-Caribbean (OR: 0.53 (95% CI 0.32 to 0.86), p = 0.04). For the A allele, a significant inverse association was observed among the cases of low-grade Gleason scores and localized clinical stage, in both populations. The long repetitions (TA) n (n> 6) rs8175347 (UGT1A1) were significantly associated with high grades (OR: 1.41 (95% CI 1.00 to 2.00)) and advanced clinical stage cancer prostate (OR: 1.56 (95% CI 1.02 to 2.37)) in Afro-Caribbean men. CONCLUSIONS Our results support the hypothesis that polymorphisms of genes encoding enzymes involved in the metabolism of oestrogen to modulate the risk of prostate cancer in populations of African origin. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e875-e876 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Laurent BRUREAU More articles by this author Dieudonne MONINGO More articles by this author Elise EMEVILLE More articles by this author Severine FERDINAND More articles by this author Marc ROMANA More articles by this author Pascal BLANCHET More articles by this author Luc MULTIGNER More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...