MP64-13 PROSTATE CANCER CHARACTERISTICS AND SURVIVAL OUTCOMES IN MEN WITH A BENIGN INITIAL PROSTATE BIOPSY: A REAL-WORLD COHORT STUDY FROM A TERTIARY REFERRAL CENTER

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History II (MP64)1 Apr 2020MP64-13 PROSTATE CANCER CHARACTERISTICS AND SURVIVAL OUTCOMES IN MEN WITH A BENIGN INITIAL PROSTATE BIOPSY: A REAL-WORLD COHORT STUDY FROM A TERTIARY REFERRAL CENTER Chi-Shin Tseng*, Kuo-How Huang, I-Ni Chiang, Hong-Chiang Chang, Chao-Yuan Huang, Yeong-Shiau Pu, and Chung-Hsin Chen Chi-Shin Tseng*Chi-Shin Tseng* More articles by this author , Kuo-How HuangKuo-How Huang More articles by this author , I-Ni ChiangI-Ni Chiang More articles by this author , Hong-Chiang ChangHong-Chiang Chang More articles by this author , Chao-Yuan HuangChao-Yuan Huang More articles by this author , Yeong-Shiau PuYeong-Shiau Pu More articles by this author , and Chung-Hsin ChenChung-Hsin Chen More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000939.013AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The negative initial prostate biopsy in men with suspected prostate cancer has an important role in oncological outcome. Repeat biopsy have been applied in many patients. We investigated the tumor characteristics and risk of mortality in men with prostate cancer diagnosed on repeat prostate biopsies. METHODS: Data of 1654 patients who underwent prostate biopsies at our institute from January 2002 to December 2005 was extracted. Patients with prostate cancer were grouped as diagnosed through first prostate biopsy (FPB) and repeat prostate biopsy (RPB). Tumor characteristics, overall survival (OS), and prostate cancer-specific survival (CSS) were further analyzed. Subgroup analyses comparing hazard ratios for mortality included factors of age, prostate-specific antigen (PSA) and number of biopsy sessions. RESULTS: A total of 620 patients were diagnosed as prostate cancer, with 466 (75.2%) on initial biopsy and 154 (24.8%) on a second or later biopsy. The FPB group was associated with more advanced tumor stage, higher Gleason score, and more positive biopsy cores. The 10-year OS proportions for the RPB and FPB groups were 87% and 69% (p= 0.002); 10-year CSS for the RPB and FPB groups were 91% and 80% (p= 0.015), respectively. Only age and the number of biopsy sessions were independent factors of OS and prostate CSS in the multivariate Cox proportional hazards model. In the subgroup of RPB with PSA level <10 ng/mL or the subgroup of RPB with younger patients (≤70 years), the 10-year OS and prostate CSS were both 100%. CONCLUSIONS: Patients with prostate cancer diagnosed through an RPB exhibited more favorable tumor characteristics, longer OS and prostate CSS than those diagnosed through initial biopsy. Either PSA value under 10 ng/mL or younger age ≤70 years added significant prognostic value after a benign initial biopsy, ensuring a very low mortality rate. Our findings could be used to inform and assess specific patients before undergoing further repeat biopsy. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e968-e968 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Chi-Shin Tseng* More articles by this author Kuo-How Huang More articles by this author I-Ni Chiang More articles by this author Hong-Chiang Chang More articles by this author Chao-Yuan Huang More articles by this author Yeong-Shiau Pu More articles by this author Chung-Hsin Chen More articles by this author Expand All Advertisement PDF downloadLoading ...