MP63-10 LOWER URINARY TRACT CALCULI IN WOMEN ARE ASSOCIATED WITH PELVIC ORGAN PROLAPSE, CHRONIC KIDNEY DISEASE, AND MORTALITY

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction II (MP63)1 Sep 2021MP63-10 LOWER URINARY TRACT CALCULI IN WOMEN ARE ASSOCIATED WITH PELVIC ORGAN PROLAPSE, CHRONIC KIDNEY DISEASE, AND MORTALITY John Weedin, Joanie Chung, and Marc Herskowitz John WeedinJohn Weedin More articles by this author , Joanie ChungJoanie Chung More articles by this author , and Marc HerskowitzMarc Herskowitz More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002103.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Lower urinary tract calculi (LUTC) is a complication of voiding dysfunction. Most LUTC research exists in men. Since LUTC are rare in women, most information is limited to case reports/series. Our goal is to characterize women with LUTC and evaluate their outcomes. METHODS: After Institutional Board Review approval, a retrospective review was conducted of women with LUTC from 2010-2019 within Kaiser Permanente of Southern California. All LUTC were confirmed by cystoscopy. Women with secondary causes of LUTC including calculi from the upper urinary tract, foreign bodies, and intestinal segments were excluded. Multiple variables associated with the evaluation and treatment of LUTC were examined. Statistical analysis was used to compare women to men with LUTC. Additionally, women with LUTC were compared 1:1 to age and gender matched controls. Length of follow up was also matched. RESULTS: After excluding 319 women with secondary causes, 135 women with primary LUTC were included. Mean age was 65.1 years and follow up was 54 months. 4 women declined treatment and 2 women passed their calculi. All LUTC were removed in one session including irrigation or manual removal (58), crushing (17), laser or pneumatic fragmentation (68), or open removal (4). LUTC composition was calcium based (65%), uric acid (23.6%), and struvite (14.2%). Compared to men, women with LUTC were younger, nonsmokers, and nonwhite ethnicity (all p<0.05). Women were less likely to have metabolic disorders like hypertension, hyperlipidemia, diabetes, and cardiovascular disease (all p<0.05). Women were more likely to have urinary infections and incontinence, but less likely to have hematuria and urinary retention than men (all p<0.05). Recurrence of LUTC was not significantly different between women and men (16.2% vs 21.5%, p=0.16). Compared to matched controls, women with LUTC were more likely to have pelvic organ prolapse (25.1%), gallstones (45.4%), aortoiliac atherosclerosis (72.0%), chronic kidney disease (25.4%), neurologic disorders (24.6%), gastrointestinal malabsorption (6.0%), and hyperparathyroidism (all p<0.05). Mortality in women with LUTC was higher than matched controls (15.7% vs 5.9%, p=0.01). CONCLUSIONS: Women with primary LUTC are a population distinct from men with LUTC and matched controls. While women with LUTC did not have a higher prevalence of metabolic and cardiovascular diseases than matched controls, they did have a higher prevalence of chronic kidney disease, neurologic, and gastrointestinal disorders that may have resulted in increased mortality. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1105-e1105 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information John Weedin More articles by this author Joanie Chung More articles by this author Marc Herskowitz More articles by this author Expand All Advertisement Loading ...