MP63-07 LONG-TERM PROGNOSIS OF LOWER URINARY TRACT FUNCTION AFTER ROBOT-ASSISTED RADICAL PROSTATECTOMY IN PATIENTS WITH PREOPERATIVELY LOW BLADDER CONTRACTILITY

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction II (MP63)1 Sep 2021MP63-07 LONG-TERM PROGNOSIS OF LOWER URINARY TRACT FUNCTION AFTER ROBOT-ASSISTED RADICAL PROSTATECTOMY IN PATIENTS WITH PREOPERATIVELY LOW BLADDER CONTRACTILITY Junya Hata, Yu Endo, Akihisa Hasegawa, Yuki Harigane, Syunta Makabe, Kei Yaginuma, Kanako Matsuoka, Akihumi Onagi, Tomoyuki Koguchi, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Soichiro Ogawa, and Yoshiyuki Kojima Junya HataJunya Hata More articles by this author , Yu EndoYu Endo More articles by this author , Akihisa HasegawaAkihisa Hasegawa More articles by this author , Yuki HariganeYuki Harigane More articles by this author , Syunta MakabeSyunta Makabe More articles by this author , Kei YaginumaKei Yaginuma More articles by this author , Kanako MatsuokaKanako Matsuoka More articles by this author , Akihumi OnagiAkihumi Onagi More articles by this author , Tomoyuki KoguchiTomoyuki Koguchi More articles by this author , Yuichi SatoYuichi Sato More articles by this author , Hidenori AkaihataHidenori Akaihata More articles by this author , Masao KataokaMasao Kataoka More articles by this author , Soichiro OgawaSoichiro Ogawa More articles by this author , and Yoshiyuki KojimaYoshiyuki Kojima More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002103.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Our previous study reported that preoperative bladder contractility index (BCI) was a predictive factor of postoperative detrusor underactivity (DU) at 1 month after robot-assisted radical prostatectomy (RARP). This result suggested that a preoperative decrease in reserve capacity of bladder function might contribute to the postoperative DU at a relatively early phase after RARP. However, the long-term prognosis of lower urinary tract function (voiding and storage function) in patients with reduced bladder contractility remained unclear. In the current prospective study, we analyzed time-dependent changes in lower urinary tract function and symptoms in patients who underwent RARP. METHODS: One hundred fifteen patients (mean age 66.6±5.0 years) who underwent RARP at our institution were enrolled in this study. Urodynamic studies (UDS) were performed before RARP in all of these patients. The patients were divided into two groups: impaired bladder contractility group (patients with BCI <100: impaired group; n=45) and preserved bladder contractility group (patients with BCI >100: preserved group; n=70). In both groups, lower urinary tract function, including maximum flow rate (Qmax), voiding volume and post-void residual volume, and lower urinary tract symptoms, including International Prostatic Symptom Score (IPSS), Quality of Life score and Overactive Bladder Symptom Score (OABSS) were evaluated at 1, 3, 6, 9 and 12 months after RARP. Furthermore, to determine the risk factors for lower BCI, we performed univariate and multivariate logistic regression analysis using patient parameters, including age, body mass index, prostate weight, diabetes and LDL-cholesterol. RESULTS: Qmax at 1, 3, 9 and 12 months after RARP were significantly lower in the impaired group than the preserved group (p<0.05, respectively). Voiding volume at 3 months after RARP was also significantly lower in the impaired group than the preserved group (p<0.01). In addition, IPSS voiding scores at 1, 3, 6, 9 and 12 months after RARP were significantly higher in the impaired group than the preserved group (p<0.05, respectively). On the other hand, no significant difference was observed in the 1-hour pad test and OABSS between impaired and preserved groups throughout the testing period. High LDL-cholesterol was identified as a risk factor for low BCI preoperatively (p=0.03, odds ratio 1.02). CONCLUSIONS: Low preoperative bladder contractility was associated with prolonged deterioration of voiding function. The results also suggested that dyslipidemia might be associated with a decrease in bladder contractility. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1104-e1104 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Junya Hata More articles by this author Yu Endo More articles by this author Akihisa Hasegawa More articles by this author Yuki Harigane More articles by this author Syunta Makabe More articles by this author Kei Yaginuma More articles by this author Kanako Matsuoka More articles by this author Akihumi Onagi More articles by this author Tomoyuki Koguchi More articles by this author Yuichi Sato More articles by this author Hidenori Akaihata More articles by this author Masao Kataoka More articles by this author Soichiro Ogawa More articles by this author Yoshiyuki Kojima More articles by this author Expand All Advertisement Loading ...