MP63-08 LOW SERUM DIHYDROTESTOSTERONE IS A POWERFUL PREDICTOR OF GLEASON SCORE 7-10 OF PROSTATE CANCER IN MEN WITH PROSTATE-SPECIFIC ANTIGEN LEVELS OF 3-10NG/ML

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening III1 Apr 2014MP63-08 LOW SERUM DIHYDROTESTOSTERONE IS A POWERFUL PREDICTOR OF GLEASON SCORE 7-10 OF PROSTATE CANCER IN MEN WITH PROSTATE-SPECIFIC ANTIGEN LEVELS OF 3-10NG/ML Yasuhide Miyoshi, Susumu Umemoto, Hiroji Uemura, Yasuhiro Shibata, Seijiro Honma, and Yoshinobu Kubota Yasuhide MiyoshiYasuhide Miyoshi More articles by this author , Susumu UmemotoSusumu Umemoto More articles by this author , Hiroji UemuraHiroji Uemura More articles by this author , Yasuhiro ShibataYasuhiro Shibata More articles by this author , Seijiro HonmaSeijiro Honma More articles by this author , and Yoshinobu KubotaYoshinobu Kubota More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1945AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES There has been no consensus on the role of androgen concentrations in prostate cancer detection in men with prostate-specific antigen (PSA) levels of 3-10 ng/mL. In this study, testosterone (T) and dihydrotestosterone (DHT) concentrations in blood and needle biopsy specimens of prostate were examined by a newly developed ultra sensitive LC-MS/MS method. METHODS We analyzed 197 men (mean age 68 years) with a total PSA range of 3-10 ng/ml who were subjected to initial prostate biopsy for suspected prostate cancer from November 2005 to July 2007. Those patients received systematic needle biopsy, and additionally one needle biopsy from the peripheral zone was conducted for the purpose of simultaneous determination of T and DHT. T and DHT concentrations in prostate tissues and blood, determined by LC-MS/MS method. Determination limits of this method was 0.5 pg/shot for T and 1 pg/shot for DHT. Concentration of T and DHT were expressed in pg/mg. T and DHT levels in tissue and blood were compared with pathological findings by multivariate analyses. RESULTS Median values of PSA and prostate volume measured by ultrasound were 5.7 ng/mL and 31.4cc respectively. Median values of T and DHT in blood were 3805.5 pg/mL and 364.4 pg/mL, respectively. There was a strong correlation between serum T and DHT. Median values of T and DHT in tissue were 0.53 pg/mg and 8.40 pg/mg, respectively. Prostate cancer was diagnosed in 82 (41.6%) of those patients including 43 (21.8%) patients with a Gleason score 7-10. In multivariate analysis, patient age (p<0.0001), prostate volume (p<0.0001), and blood DHT (p<0.01) were statistically significant predictors of prostate cancer with Gleason score 7-10. The areas under the curve of the receiver operating characteristic curve for age, prostate volume, and blood DHT were 0.658, 0.689, and 0.638, respectively. CONCLUSIONS Testosterone and dihydrotestosterone concentrations in blood or prostate tissue of needle biopsy were simultaneously examined by the newly developed ultra sensitive quantifying method, LC-MS/MS. We confirmed that low dihydrotestosterone levels in blood could predict prostate cancer with a Gleason score 7-10 in men with prostate-specific antigen levels of 3-10ng/mL. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e711-e712 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Yasuhide Miyoshi More articles by this author Susumu Umemoto More articles by this author Hiroji Uemura More articles by this author Yasuhiro Shibata More articles by this author Seijiro Honma More articles by this author Yoshinobu Kubota More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...