MP63-06 DIASTOLIC BLOOD PRESSURE REDUCTION IS ASSOCIATED WITH IMPROVEMENT IN NOCTURIA

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Non-neurogenic Voiding Dysfunction II (MP63)1 Sep 2021MP63-06 DIASTOLIC BLOOD PRESSURE REDUCTION IS ASSOCIATED WITH IMPROVEMENT IN NOCTURIA Connelly Miller, Thomas Monaghan, Dennis Robins, Christina Agudelo, Jason Lazar, and Jeffrey Weiss Connelly MillerConnelly Miller More articles by this author , Thomas MonaghanThomas Monaghan More articles by this author , Dennis RobinsDennis Robins More articles by this author , Christina AgudeloChristina Agudelo More articles by this author , Jason LazarJason Lazar More articles by this author , and Jeffrey WeissJeffrey Weiss More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002103.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Several atherosclerotic cardiovascular disease risk factors including hypertension and hypercholesterolemia have been implicated in increased incidence and severity of nocturia. We aimed to assess the impact of reduction in blood pressure and cholesterol on nocturnal urinary frequency. METHODS: We performed a retrospective analysis of voiding diaries completed by patients treated for lower urinary tract symptoms at a Veterans Affairs urology clinic. Contemporaneous measurements of systolic and diastolic blood pressure and total and LDL cholesterol were abstracted from the visit corresponding to each diary entry. Adult male patients with ≥2 diaries separated by ≥30 days who experienced a reduction in any cardiovascular risk parameter by ≥10% from baseline to follow-up were included in the present analysis. Mean nocturnal voids, nocturnal urine volume, 24-hour voids, 24-hour urine volume, and maximum voided volume were compared. Linear regression was used to adjust for age and race. RESULTS: Patients with a ≥10% reduction in diastolic blood pressure (n=74) experienced a crude reduction in nocturnal voids which trended towards significance (2.6 vs. 2.1, crude β-coefficient=-0.059, p=0.07); this became significant after adjustment for age (adjusted β-coefficient=-0.073, p=.04) and remained significant upon further adjustment for race (adjusted β-coefficient=-0.073, p=.04). Nocturnal urine volume (744 mL vs. 691 mL, p=.55), 24-hour voids (11.3 vs. 10.7, p=.24), 24-hour urine volume (2,033 mL vs. 1,923 mL, p=.56), and maximum voided volume (301 mL vs. 305 mL, p=.90) did not significantly change with reduction in diastolic blood pressure. No significant changes were observed in diary characteristics among patients who experienced ≥10% reductions in systolic blood pressure (n=57), total cholesterol (n=49), or LDL cholesterol (n=72). CONCLUSIONS: Reduction in diastolic blood pressure was associated with improvement in nocturia severity after adjustment for relevant covariates. This link between cardiovascular health and nocturia carries potential important public health implications. Prospective longitudinal research to further elucidate this relationship is warranted. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1103-e1104 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Connelly Miller More articles by this author Thomas Monaghan More articles by this author Dennis Robins More articles by this author Christina Agudelo More articles by this author Jason Lazar More articles by this author Jeffrey Weiss More articles by this author Expand All Advertisement Loading ...