MP62-13 ASSOCIATION OF PROSTATE CANCER POLYGENIC RISK SCORE WITH NUMBER AND LATERALITY OF TUMOR CORES IN ACTIVE SURVEILLANCE PATIENTS

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Active Surveillance II (MP62)1 Sep 2021MP62-13 ASSOCIATION OF PROSTATE CANCER POLYGENIC RISK SCORE WITH NUMBER AND LATERALITY OF TUMOR CORES IN ACTIVE SURVEILLANCE PATIENTS Jianfeng Xu, William Isaacs, Mufaddal Mamawala, Zhuqing Shi, Patricia Landis, Jacqueline Petkewicz, Jun Wei, W. Kyle Resurreccion, Rong Na, Yasin Bhanji, Kristian Novakovic, Patrick Walsh, S. Lilly Zheng, Brian Helfand, and Christian Pavlovich Jianfeng XuJianfeng Xu More articles by this author , William IsaacsWilliam Isaacs More articles by this author , Mufaddal MamawalaMufaddal Mamawala More articles by this author , Zhuqing ShiZhuqing Shi More articles by this author , Patricia LandisPatricia Landis More articles by this author , Jacqueline PetkewiczJacqueline Petkewicz More articles by this author , Jun WeiJun Wei More articles by this author , W. Kyle ResurreccionW. Kyle Resurreccion More articles by this author , Rong NaRong Na More articles by this author , Yasin BhanjiYasin Bhanji More articles by this author , Kristian NovakovicKristian Novakovic More articles by this author , Patrick WalshPatrick Walsh More articles by this author , S. Lilly ZhengS. Lilly Zheng More articles by this author , Brian HelfandBrian Helfand More articles by this author , and Christian PavlovichChristian Pavlovich More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002102.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer (PCa) is characterized by its tendency to be multifocal. However, few studies have investigated the endogenous factors that explain multifocal disease. The primary objective of the current study is to test whether inherited PCa risk is associated with multifocal tumors in PCa patients. METHODS: Subjects in this study were Caucasian PCa patients undergoing active surveillance (AS) at Johns Hopkins Hospital (JHH, N=805) and NorthShore University HealthSystem (NSUHS, N=432). Inherited risk was measured by genetic risk score (GRS), an odds ratio (OR)-weighted and population-standardized polygenic risk score based on known risk-associated SNPs. PCa multifocality was indirectly measured by the number and laterality of positive tumor cores from a 12-core systematic biopsy. RESULTS: In the combined cohort, 36% and 66% of patients had ≥2 tumor cores at the initial diagnostic biopsy and on at least one subsequent surveillance biopsy, respectively. For tumor laterality, 8.0% and 47% patients had bilateral tumor cores at diagnostic and surveillance biopsies, respectively. We found, for the first time, that patients with higher numbers of positive cores at diagnostic and surveillance biopsies, respectively, had significantly higher mean GRS values, p=0.02 and p<0.001 (Table). Additionally, patients with bilateral tumors at diagnostic and surveillance biopsies, respectively, had significantly higher mean GRS values than those with unilateral tumors, p=0.005 and p=0.03. In contrast, no association was found between GRS and maximum core length of tumor or tumor grade at diagnostic/surveillance biopsies (all p>0.05). Finally, we observed a modest trend that patients with higher GRS quartiles had higher risk for tumor upgrading on surveillance biopsies. The trend, however, was not statistically significant (p>0.05). CONCLUSIONS: The associations of GRS with two measurements of PCa multifocality (core numbers and laterality) provide novel and consistent evidence for the link between inherited PCa risk and multifocal tumors. Source of Funding: This study was partially supported by grants from Department of Defense (W81XWH-16-1-0764, W81XWH-16-1-0765, and W81XWH-16-1-0766) and the National Cancer Institute (P30CA006973) © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1097-e1097 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jianfeng Xu More articles by this author William Isaacs More articles by this author Mufaddal Mamawala More articles by this author Zhuqing Shi More articles by this author Patricia Landis More articles by this author Jacqueline Petkewicz More articles by this author Jun Wei More articles by this author W. Kyle Resurreccion More articles by this author Rong Na More articles by this author Yasin Bhanji More articles by this author Kristian Novakovic More articles by this author Patrick Walsh More articles by this author S. Lilly Zheng More articles by this author Brian Helfand More articles by this author Christian Pavlovich More articles by this author Expand All Advertisement Loading ...