MP60-18 DECREASED CONTRACTILITY AND INCREASED RESIDUAL URINE VOLUME OF THE BLADDER IN A CHRONIC ISCHEMIC MODEL IN THE RAT; A POSSIBLE PATH TO THE UNDERACTIVE BLADDER

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology I1 Apr 2016MP60-18 DECREASED CONTRACTILITY AND INCREASED RESIDUAL URINE VOLUME OF THE BLADDER IN A CHRONIC ISCHEMIC MODEL IN THE RAT; A POSSIBLE PATH TO THE UNDERACTIVE BLADDER Norifumi Sawada, Satoru Kira, Takahiko Mitsui, and Masayuki Takeda Norifumi SawadaNorifumi Sawada More articles by this author , Satoru KiraSatoru Kira More articles by this author , Takahiko MitsuiTakahiko Mitsui More articles by this author , and Masayuki TakedaMasayuki Takeda More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.871AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Epidemiological studies have shown the close relationship between lower urinary tract symptoms and vascular endothelial dysfunction due to atherosclerosis in the elderly. Thus atherosclerotic changes in the pelvic vasculature may be an important contributing factor to the etiology of urinary tract symptoms. Clinically, detrusor underactivity is diagnosed based on urodynamic exam, defined as a contraction of decreased strength, sometimes with failure to achieve complete bladder emptying. This clinical condition is supposed to occur in a long period and progressive vascular damage might be involved. To check the chronic effect of atherosclerosis, we have examined the bladder function of the rats with arterial endothelial injury of the common iliac arteries for a longer period. METHODS Adult male Sprague Dawley rats were divided into 2 groups. Control received a regular diet and tap water. The arterial injury group underwent balloon endothelial injury of the common iliac arteries and received a 2% cholesterol diet and tap water after injury. At 16 weeks urodynamics were performed, bladder tissue was harvested for pharmacological studies, and the iliac arteries and bladders were histologically examined. RESULTS Iliac arteries from the injury groups showed neointimal formation. In the injury group, bladder capacity and voided volume were less than controls (Table 1). Cystometry showed increased residual volume of urine in the injury groups (Table 1). The responses to carbachol were lower in the AI-groups than in the controls (Fig.1A). The EFS-elicited contractile responses of the bladder strips had a trend of less strength than in controls in injury groups (Fig.1B,C). CONCLUSIONS Pelvic arterial occlusive disease may cause the decreased strength of contraction and increased residual volume of urine of the bladder. This model might show a point midway between overactive and underactive bladder. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e801 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Norifumi Sawada More articles by this author Satoru Kira More articles by this author Takahiko Mitsui More articles by this author Masayuki Takeda More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...