MP60-05 MELATONIN HORMONE LEVEL IN SERUM AND SEMINAL PLASMA OF PATIENTS WITH IDIOPATHIC OLIGOASTHENOTERATOZOOSPERMIA

Abstract

You have accessJournal of UrologyInfertility: Basic Research & Pathophysiology1 Apr 2018MP60-05 MELATONIN HORMONE LEVEL IN SERUM AND SEMINAL PLASMA OF PATIENTS WITH IDIOPATHIC OLIGOASTHENOTERATOZOOSPERMIA Hassan Ibrahim, Moustafa El Taieb, Hanan Fayed, and Nahed Fares Hassan IbrahimHassan Ibrahim More articles by this author , Moustafa El TaiebMoustafa El Taieb More articles by this author , Hanan FayedHanan Fayed More articles by this author , and Nahed FaresNahed Fares More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1897AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Melatonin is a sleep inducing hormone and a hormone of darkness, secreted by the pineal gland. It has a role in idiopathic oligoasthenoteratozoospermia (iOAT) male infertility by its potent antioxidant effect. We aim to estimate seminal plasma and serum melatonin levels in iOAT patients compared with normal fertile male patients and the effect of exposure to light at night on their semen parameters. METHODS A clinical cross- sectional case control study, in which semen and serum samples were collected from 50 infertile men ( 34 men exposed to light at night an 16 men not exposed) and 50 fertile ones. WHO, 2010 semen analysis was done. Serum and seminal plasma were assessed for melatonin level using enzyme-linked immunosorbent assay (ELISA). RESULTS There was significant decrease in seminal plasma and serum melatonin levels in iOAT patients (P=0.0004,P=0.01) respectively in comparative to control group (Table a). Statistically significant decrease was found in the serum and seminal plasma levels of melatonin hormone in exposed cases to light at night (night shift work) than non-exposed cases (P< 0.0001), (P= 0.02) respectively (Table b). There was also a negative significant correlation between semen parameters of iOAT patients (concentration, motility and abnormal forms) and exposure to light at night (p<0.0001), (p=0.04) and (p=0.04) respectively. CONCLUSIONS Darkening and sleep at night may improve semen parameters in iOAT patients via the antioxidant activity of melatonin hormone in the serum and seminal plasma as demonstrated by the negative effect of exposure to light at night on serum and seminal plasma level of melatonin and consequently on the semen parameters. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e791 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Hassan Ibrahim More articles by this author Moustafa El Taieb More articles by this author Hanan Fayed More articles by this author Nahed Fares More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...