MP60-11 A PRELIMINARY STUDY OF SEX DIFFERENCES IN PREFRONTAL CORTICAL OXYHEMOGLOBIN CONCENTRATION DURING NATURAL BLADDER FILLING

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP60-11 A PRELIMINARY STUDY OF SEX DIFFERENCES IN PREFRONTAL CORTICAL OXYHEMOGLOBIN CONCENTRATION DURING NATURAL BLADDER FILLING Gabrielle Grob, Helen Query, Linda S. Burkett, Peter Daniels, Mina P. Ghatas, Michael Shields, Devin Rogers, abigail Kaufmann, Lynn Stothers, Adam P. Klausner, and John E. Speich Gabrielle GrobGabrielle Grob More articles by this author , Helen QueryHelen Query More articles by this author , Linda S. BurkettLinda S. Burkett More articles by this author , Peter DanielsPeter Daniels More articles by this author , Mina P. GhatasMina P. Ghatas More articles by this author , Michael ShieldsMichael Shields More articles by this author , Devin RogersDevin Rogers More articles by this author , abigail Kaufmannabigail Kaufmann More articles by this author , Lynn StothersLynn Stothers More articles by this author , Adam P. KlausnerAdam P. Klausner More articles by this author , and John E. SpeichJohn E. Speich More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003318.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Sex differences during bladder filling are poorly understood. Functional near infrared spectroscopy (fNIRS) allows non-invasive measurement of cortical brain oxygenated hemoglobin concentration (O2Hb), which has been shown to increase during bladder filling. The objective of this study was to use fNIRS to compare differences between sexes in cortical O2Hb during natural bladder filling. METHODS: Control participants with no known urologic conditions and a negative urgency screen (ICIq-OAB and OAB-V3 surveys) completed a validated oral hydration protocol. During the protocol, participants recorded real-time sensation of bladder fullness (0-100%) and reported “first desire” to void using a Sensation Meter. Prefrontal cortical fNIRS continuous recording of O2Hb was completed during filling and voiding with a 24 channel template. Matlab was used to analyze data between “first desire” to void and 100% sensation, defined in this study as the period of “elevated urgency.” Channels were sub-divided by cortical regions: right (9), left (9), middle (6). RESULTS: Male (n=4) and female (n=4) participants were enrolled with mean age of 39 years and BMI of 25. There were no differences in age, BMI, race, daily fluid intake or OAB scores between sexes. Mean time between first desire and 100% sensation (minutes) was 12.9±6.01 and did not differ between groups (13.8±7.97 female vs 12.0±4.3 male, p=0.70). The difference in O2Hb throughout high urgency was similar between groups in each of the 24 individual channels, with greatest changes in the lateral prefrontal cortex (figure 1). The association between the change in O2Hb and filling did not differ between sexes (R-squared > 0.5 in 72.9% females and 82.3% males, p=0.27). O2Hb generally increased with a positive slope of the exponential fitted curve in 92% participants and did not differ between sexes by individual participant or in all 24 channels. CONCLUSIONS: We found that prefrontal cortical O2Hb concentration generally increases during natural filling and does not appear to differ between male and female controls. Ultimately, fNIRS might enable objective identification of specific neuroexcitation patterns to allow office-based diagnosis and improved treatment of voiding dysfunction. Source of Funding: NIH R21DK128649 & K12HD108269, VCU Presidential Research Quest Fund © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e847 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gabrielle Grob More articles by this author Helen Query More articles by this author Linda S. Burkett More articles by this author Peter Daniels More articles by this author Mina P. Ghatas More articles by this author Michael Shields More articles by this author Devin Rogers More articles by this author abigail Kaufmann More articles by this author Lynn Stothers More articles by this author Adam P. Klausner More articles by this author John E. Speich More articles by this author Expand All Advertisement PDF downloadLoading ...