MP60-10 FUNCTIONAL ULTRASOUND IMAGING OF HUMAN SPINAL CORD CAPTURES THE SPATIOTEMPORAL MODULATION OF SPINAL CORD HEMODYNAMICS DURING MICTURITION

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP60-10 FUNCTIONAL ULTRASOUND IMAGING OF HUMAN SPINAL CORD CAPTURES THE SPATIOTEMPORAL MODULATION OF SPINAL CORD HEMODYNAMICS DURING MICTURITION Aidin Abedi, Kofi Agyeman, Darrin J Lee, Evgeniy Kreydin, David Chapman, Jonathan J Russin, Wooseong Choi, V Reggie Edgerton, Charles Y Liu, and Vassilios N Christopoulos Aidin AbediAidin Abedi More articles by this author , Kofi AgyemanKofi Agyeman More articles by this author , Darrin J LeeDarrin J Lee More articles by this author , Evgeniy KreydinEvgeniy Kreydin More articles by this author , David ChapmanDavid Chapman More articles by this author , Jonathan J RussinJonathan J Russin More articles by this author , Wooseong ChoiWooseong Choi More articles by this author , V Reggie EdgertonV Reggie Edgerton More articles by this author , Charles Y LiuCharles Y Liu More articles by this author , and Vassilios N ChristopoulosVassilios N Christopoulos More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003318.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Unlike the brain, functional imaging of the spinal cord has been elusive. This is due to the small size of the spinal cord and limitations of the neuroimaging techniques. The functional ultrasound imaging (fUSI) is a novel neuroimaging technique with superior spatiotemporal properties that can detect microvascular changes correlated to changes in neural activity. The objective of this study is to determine whether fUSI can detect and characterize the spatial and temporal hemodynamic changes in the human spinal cord in response to bladder filling and emptying. METHODS: Four patients, who were undergoing standard-of-care implantation of a spinal cord stimulator, were enrolled in the study. Following exposure of the spinal cord during implantation of the spinal cord stimulator, the fUSI probe was positioned over the spinal cord at thoracic level 10. Images were acquired during two bladder-filling cycles and one emptying cycle with intermittent holding periods. The bladder pressure dynamics and power Doppler signal were correlated to determine the spinal cord regions associated with micturition. RESULTS: Several regions of interest (ROIs) exhibiting differential activation in response to changes in detrusor pressure were identified. The ROIs were primarily localized to the dorsal spinal cord. Most regions exhibited an increase in power Doppler signal during bladder filling and a decrease in signal with bladder emptying. However, other regions exhibited a reverse pattern with signal reduction during bladder filling and signal increase during emptying (Figure 1). CONCLUSIONS: This is the first in-human application of ultrafast ultrasound to study the neurovascular coupling changes that occur in the spinal cord as a result of bladder filling and emptying. The ability to characterize and correlate spinal cord hemodynamics to micturition events holds promise to help further understand functional and dysfunctional anatomy associated with lower urinary tract physiology. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e847 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Aidin Abedi More articles by this author Kofi Agyeman More articles by this author Darrin J Lee More articles by this author Evgeniy Kreydin More articles by this author David Chapman More articles by this author Jonathan J Russin More articles by this author Wooseong Choi More articles by this author V Reggie Edgerton More articles by this author Charles Y Liu More articles by this author Vassilios N Christopoulos More articles by this author Expand All Advertisement PDF downloadLoading ...